SCHEMBL7420000

SCHEMBL7420000

Cc1ccc(S(=O)(=O)C(=O)[C@@H](N)Cc2[c][nH]cn2)cc1

nearest known ligand 0.37

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
SLC1A3 P43003 1/20 0.36
SLC1A2 P43004 1/20 0.36
SLC1A1 P43005 1/20 0.36
ALDH1A1 P00352 4/20 0.36
GBA1 P04062 1/20 0.34
LMNA P02545 3/20 0.33
POLB P06746 2/20 0.33
KMT2A Q03164 3/20 0.33
RAB9A P51151 1/20 0.33
CA12 O43570 1/20 0.33
CA1 P00915 1/20 0.33
CA2 P00918 1/20 0.33
CA3 P07451 1/20 0.33
CA6 P23280 1/20 0.33
CA5A P35218 1/20 0.33
CA7 P43166 1/20 0.33
CA9 Q16790 1/20 0.33
CA5B Q9Y2D0 1/20 0.33
NOD2 Q9HC29 2/20 0.32
SMN1; SMN2 Q16637 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL5702193 0.76 CYP3A4 (0.55) ALDH1A1LMNAKMT2ACA1CA2
SCHEMBL31643303 0.72 ALDH1A1 (0.44) SLC1A3SLC1A2SLC1A1ALDH1A1GBA1
SCHEMBL31643134 0.69 GSR (0.42) SLC1A3SLC1A2SLC1A1ALDH1A1GBA1
SCHEMBL15759952 0.66 ALDH1A1 (0.40) SLC1A3SLC1A2SLC1A1ALDH1A1GBA1
SCHEMBL3939051 0.63 GAA (0.44) ALDH1A1LMNAKMT2ACA12CA1
SCHEMBL5702179 0.63 ITGB3 (0.44) SLC1A3SLC1A2SLC1A1ALDH1A1GBA1
SCHEMBL8630587 0.63 LARS1 (0.40) SLC1A3SLC1A2SLC1A1ALDH1A1GBA1
SCHEMBL179723 0.61 ALDH1A1 (0.57) ALDH1A1LMNAPOLBKMT2ACA12
SCHEMBL27914208 0.61 GAA (0.56) ALDH1A1LMNAPOLBKMT2ACA12
SCHEMBL29988897 0.61 ALDH1A1 (0.52) ALDH1A1LMNAPOLBKMT2ARAB9A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0349570-A1 RENIN INHIBITORS CONTAINING A CYCLOPROPYL AMINO ACID AND/OR A CYCLOALKYL TRANSITION-STATE ANALOGUE THE UPJOHN COMPANY (US) 1990-01-10 EP disclosed
WO-1988007053-A1 RENIN INHIBITORS CONTAINING A CYCLOPROPYL AMINO ACID AND/OR A CYCLOALKYL TRANSITION-STATE ANALOGUE THE UPJOHN COMPANY (US) 1988-09-22 WO disclosed