Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PKM | P14618 | 1/20 | 0.56 |
| ▸ | MAPT | P10636 | 2/20 | 0.52 |
| ▸ | NPC1 | O15118 | 1/20 | 0.52 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.52 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.52 |
| ▸ | RAB9A | P51151 | 1/20 | 0.52 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.52 |
| ▸ | RELA | Q04206 | 1/20 | 0.52 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.43 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.41 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.41 |
| ▸ | SLC5A1 | P13866 | 1/20 | 0.41 |
| ▸ | SLC5A2 | P31639 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6070326 | 0.84 | PKM (0.62) | PKMMAPTNPC1NFKB1MAPK1 | |
| SCHEMBL7420258 | 0.83 | SLC5A1 (0.55) | MAPTNPC1NFKB1MAPK1RAB9A | |
| SCHEMBL28827450 | 0.78 | PKM (0.49) | PKMMAPTNPC1NFKB1MAPK1 | |
| SCHEMBL25429598 | 0.76 | MAPT (0.54) | PKMMAPTNPC1NFKB1MAPK1 | |
| SCHEMBL30535288 | 0.76 | MAPT (0.54) | PKMMAPTNPC1NFKB1MAPK1 | |
| SCHEMBL7479238 | 0.75 | ALDH1A1 (0.57) | MAPTNPC1MAPK1RAB9APDE4B | |
| SCHEMBL7473041 | 0.74 | PDE4B (0.72) | MAPTNPC1RAB9APDE4BPDE4D | |
| SCHEMBL6597210 | 0.74 | MAPT (0.60) | MAPTNPC1NFKB1MAPK1RAB9A | |
| SCHEMBL6070770 | 0.73 | PKM (0.62) | PKMMAPTNPC1NFKB1RAB9A | |
| SCHEMBL6461061 | 0.73 | CA9 (0.50) | PKMMAPTNPC1NFKB1MAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1248781-A1 | PYRAZOLE CYCLIC AMP-SPECIFIC PDE INHIBITORS | ICOS CORPORATION (US) | 2002-10-16 | — | — | EP | disclosed |
| WO-2001046172-A1 | PYRAZOLE CYCLIC AMP-SPECIFIC PDE INHIBITORS | ICOS CORPORATION (US) | 2001-06-28 | — | — | WO | disclosed |