Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FAAH | O00519 | 1/20 | 0.42 |
| ▸ | LTB4R | Q15722 | 1/20 | 0.41 |
| ▸ | LTB4R2 | Q9NPC1 | 1/20 | 0.41 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.41 |
| ▸ | KAT6A | Q92794 | 1/20 | 0.41 |
| ▸ | ACHE | P22303 | 1/20 | 0.41 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.41 |
| ▸ | FOS | P01100 | 1/20 | 0.40 |
| ▸ | JUN | P05412 | 1/20 | 0.40 |
| ▸ | PTGES | O14684 | 1/20 | 0.40 |
| ▸ | CYSLTR2 | Q9NS75 | 1/20 | 0.39 |
| ▸ | CYSLTR1 | Q9Y271 | 1/20 | 0.39 |
| ▸ | PPARG | P37231 | 2/20 | 0.39 |
| ▸ | PPARA | Q07869 | 2/20 | 0.39 |
| ▸ | AOC3 | Q16853 | 1/20 | 0.39 |
| ▸ | CYP2D6 | P10635 | 3/20 | 0.38 |
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.38 |
| ▸ | PPARD | Q03181 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6834465 | 0.86 | LTB4R (0.45) | LTB4RLTB4R2ALOX5NR1H4PTGES | |
| SCHEMBL7424530 | 0.85 | LTB4R (0.44) | LTB4RLTB4R2ALOX5PTGESCYSLTR2 | |
| SCHEMBL7421892 | 0.85 | NR4A2 (0.51) | LTB4RLTB4R2ALOX5 | |
| SCHEMBL7427123 | 0.85 | LTB4R (0.44) | LTB4RLTB4R2ALOX5PTGESCYSLTR2 | |
| SCHEMBL7426641 | 0.85 | LTB4R (0.47) | LTB4RLTB4R2ALOX5PTGESCYSLTR2 | |
| SCHEMBL7424454 | 0.85 | NR4A2 (0.49) | LTB4RLTB4R2ALOX5PTGESCYP2D6 | |
| SCHEMBL7424281 | 0.83 | NR4A2 (0.49) | LTB4RLTB4R2ALOX5PTGESCYSLTR2 | |
| SCHEMBL7378945 | 0.81 | MEN1 (0.48) | AOC3 | |
| SCHEMBL7428411 | 0.79 | CYP1A1 (0.40) | PTGESAOC3CYP2D6 | |
| SCHEMBL7423137 | 0.78 | FFAR1 (0.48) | ACHE |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2002039997-A2 | ACE-2 MODULATING COMPOUNDS AND USE THEREOF | MILLENNIUM PHARMACEUTICALS, INC. (US) | 2002-05-23 | — | — | WO | claimed |
| WO-2002039997-A2 | ACE-2 MODULATING COMPOUNDS AND USE THEREOF | MILLENNIUM PHARMACEUTICALS, INC. (US) | 2002-05-23 | — | — | WO | disclosed |