Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PKM | P14618 | 2/20 | 0.65 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.63 |
| ▸ | HTT | P42858 | 2/20 | 0.63 |
| ▸ | CYP19A1 | P11511 | 3/20 | 0.58 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.57 |
| ▸ | LMNA | P02545 | 2/20 | 0.53 |
| ▸ | MAPT | P10636 | 1/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7423847 | 0.85 | SMN1; SMN2 (0.71) | PKMSMN1; SMN2HTTCYP19A1MAPK1 | |
| SCHEMBL7415584 | 0.85 | SMN1; SMN2 (0.78) | PKMSMN1; SMN2HTTMAPK1LMNA | |
| SCHEMBL4104329 | 0.84 | CYP19A1 (0.82) | PKMSMN1; SMN2HTTCYP19A1LMNA | |
| SCHEMBL7425436 | 0.79 | PKM (0.82) | PKMSMN1; SMN2HTTKMT2AALDH1A1 | |
| SCHEMBL7420203 | 0.78 | SMN1; SMN2 (0.70) | PKMSMN1; SMN2HTTMAPK1LMNA | |
| SCHEMBL7425093 | 0.78 | PKM (0.66) | PKMSMN1; SMN2HTTKMT2AALDH1A1 | |
| SCHEMBL7420169 | 0.77 | MAPK1 (0.76) | PKMSMN1; SMN2HTTMAPK1LMNA | |
| SCHEMBL7425706 | 0.77 | SMN1; SMN2 (1.00) | PKMSMN1; SMN2HTTMAPK1LMNA | |
| SCHEMBL22489811 | 0.77 | CYP19A1 (0.80) | CYP19A1MAPK1LMNAKMT2AALDH1A1 | |
| SCHEMBL28195553 | 0.77 | HTT (0.75) | PKMSMN1; SMN2HTTCYP19A1MAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1996036595-A1 | 3,4-DISUBSTITUTED-PHENYLSULPHONAMIDES AND THEIR THERAPEUTIC USE | CHIROSCIENCE LIMITED (GB) | 1996-11-21 | — | — | WO | disclosed |