Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.71 |
| ▸ | HTT | P42858 | 2/20 | 0.71 |
| ▸ | PKM | P14618 | 1/20 | 0.66 |
| ▸ | TP53 | P04637 | 1/20 | 0.58 |
| ▸ | MAPT | P10636 | 1/20 | 0.58 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.57 |
| ▸ | RAB9A | P51151 | 1/20 | 0.56 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.56 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.55 |
| ▸ | LMNA | P02545 | 2/20 | 0.54 |
| ▸ | PDE4A | P27815 | 1/20 | 0.54 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.54 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.54 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7415584 | 0.86 | SMN1; SMN2 (0.78) | SMN1; SMN2HTTPKMMAPTMAPK1 | |
| SCHEMBL7420835 | 0.85 | PKM (0.65) | SMN1; SMN2HTTPKMMAPTMAPK1 | |
| SCHEMBL7425706 | 0.83 | SMN1; SMN2 (1.00) | SMN1; SMN2HTTPKMMAPK1RAB9A | |
| SCHEMBL3914871 | 0.81 | ALDH1A1 (0.76) | SMN1; SMN2HTTPKMMAPTRAB9A | |
| SCHEMBL28003775 | 0.79 | SMN1; SMN2 (0.74) | SMN1; SMN2HTTMAPTCYP19A1ALDH1A1 | |
| SCHEMBL4182162 | 0.79 | KMT2A (0.77) | SMN1; SMN2HTTMAPK1KMT2AALDH1A1 | |
| SCHEMBL7420203 | 0.78 | SMN1; SMN2 (0.70) | SMN1; SMN2HTTPKMMAPTMAPK1 | |
| SCHEMBL5960118 | 0.78 | ALDH1A1 (0.76) | SMN1; SMN2MAPTKMT2AALDH1A1 | |
| SCHEMBL31078371 | 0.77 | SMN1; SMN2 (0.77) | SMN1; SMN2HTTPKMKMT2AALDH1A1 | |
| SCHEMBL4609361 | 0.77 | ALDH1A1 (0.74) | SMN1; SMN2HTTMAPK1KMT2AALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1996036595-A1 | 3,4-DISUBSTITUTED-PHENYLSULPHONAMIDES AND THEIR THERAPEUTIC USE | CHIROSCIENCE LIMITED (GB) | 1996-11-21 | — | — | WO | disclosed |