Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.47 |
| ▸ | HPGD | P15428 | 3/20 | 0.47 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.42 |
| ▸ | MEN1 | O00255 | 4/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.42 |
| ▸ | MAPT | P10636 | 3/20 | 0.42 |
| ▸ | NPC1 | O15118 | 3/20 | 0.42 |
| ▸ | RAB9A | P51151 | 2/20 | 0.42 |
| ▸ | LMNA | P02545 | 2/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | TOP2A | P11388 | 1/20 | 0.40 |
| ▸ | APOBEC3G | Q9HC16 | 2/20 | 0.39 |
| ▸ | HTT | P42858 | 2/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.38 |
| ▸ | GFER | P55789 | 2/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | ADK | P55263 | 1/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 3/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7422898 | 0.80 | KDM4E (0.55) | KDM4EHPGDHSD17B10ALDH1A1MEN1 | |
| SCHEMBL9984386 | 0.67 | KDM4E (0.65) | KDM4EHPGDHSD17B10ALDH1A1MEN1 | |
| SCHEMBL16586809 | 0.66 | KDM4E (0.63) | KDM4EHPGDHSD17B10ALDH1A1MEN1 | |
| SCHEMBL12145700 | 0.66 | KDM4E (0.50) | KDM4EHPGDHSD17B10ALDH1A1MEN1 | |
| SCHEMBL30636803 | 0.64 | KDM4E (1.00) | KDM4EHPGDHSD17B10ALDH1A1MEN1 | |
| SCHEMBL7330343 | 0.64 | KDM4E (0.57) | KDM4EHPGDHSD17B10ALDH1A1MEN1 | |
| SCHEMBL10969790 | 0.64 | KDM4E (0.57) | KDM4EHPGDHSD17B10ALDH1A1MEN1 | |
| SCHEMBL4787828 | 0.64 | KDM4E (1.00) | KDM4EHPGDHSD17B10ALDH1A1MEN1 | |
| SCHEMBL12145661 | 0.64 | KDM4E (0.57) | KDM4EHPGDHSD17B10ALDH1A1MEN1 | |
| SCHEMBL12145663 | 0.63 | KDM4E (0.51) | KDM4EHPGDHSD17B10ALDH1A1MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1999018106-A1 | NOVEL 1,2,4-TRIAZOLO[4,3-C]QUINAZOLIN-3-ONES AND 1,2,4-TRIAZOLO[4,3-C]QUINAZOLIN-3-THIONES; A NEW CLASS OF GABA BRAIN RECEPTOR LIGANDS | NEUROGEN CORPORATION (US) | 1999-04-15 | — | — | WO | disclosed |
| WO-1999018106-A1 | NOVEL 1,2,4-TRIAZOLO[4,3-C]QUINAZOLIN-3-ONES AND 1,2,4-TRIAZOLO[4,3-C]QUINAZOLIN-3-THIONES; A NEW CLASS OF GABA BRAIN RECEPTOR LIGANDS | NEUROGEN CORPORATION (US) | 1999-04-15 | — | — | WO | disclosed |