Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTSL | P07711 | 10/20 | 0.36 |
| ▸ | CTSS | P25774 | 8/20 | 0.36 |
| ▸ | CTSK | P43235 | 7/20 | 0.36 |
| ▸ | CTSB | P07858 | 5/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | ADRB1 | P08588 | 2/20 | 0.35 |
| ▸ | NR3C2 | P08235 | 1/20 | 0.34 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.34 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.34 |
| ▸ | CTSF | Q9UBX1 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7419241 | 0.91 | CTSL (0.43) | CTSLCTSSCTSKCTSBKDM4E | |
| SCHEMBL7014338 | 0.87 | CTSS (0.44) | CTSLCTSSCTSKCTSBALDH1A1 | |
| SCHEMBL7420985 | 0.80 | ALDH1A1 (0.43) | KDM4EALDH1A1ADRB1NR3C2EPHX2 | |
| SCHEMBL7014342 | 0.80 | CTSS (0.41) | CTSSKDM4EALDH1A1ADRB1EPHX2 | |
| SCHEMBL7414895 | 0.79 | CTSL (0.47) | CTSLCTSS | |
| SCHEMBL7423676 | 0.75 | CTSL (0.44) | CTSLCTSSCTSKCTSBCTSF | |
| SCHEMBL7419135 | 0.74 | CTSS (0.45) | CTSLCTSSCTSKCTSB | |
| SCHEMBL7013440 | 0.71 | CTSL (0.40) | CTSLCTSSCTSKCTSBALDH1A1 | |
| SCHEMBL7414874 | 0.71 | CTSS (0.46) | CTSLCTSSCTSKCTSB | |
| SCHEMBL7021242 | 0.71 | CTSL (0.39) | CTSLCTSSCTSKCTSB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1218372-A1 | NOVEL SPIROHETEROCYCLIC COMPOUNDS USEFUL AS REVERSIBLE INHIBITORS OF CYSTEINE PROTEASES | Boehringer Ingelheim Pharmaceuticals, Inc. (US) | 2002-07-03 | — | — | EP | disclosed |
| WO-2001019816-A1 | NOVEL SPIROHETEROCYCLIC COMPOUNDS USEFUL AS REVERSIBLE INHIBITORS OF CYSTEINE PROTEASES | BOEHRINGER INGELHEIM PHARMACEUTICALS, INC. (US) | 2001-03-22 | — | — | WO | disclosed |