Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTSL | P07711 | 13/20 | 0.43 |
| ▸ | CTSS | P25774 | 8/20 | 0.43 |
| ▸ | CTSB | P07858 | 8/20 | 0.43 |
| ▸ | CTSK | P43235 | 7/20 | 0.43 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | ATM | Q13315 | 1/20 | 0.37 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7420982 | 0.91 | CTSL (0.36) | CTSLCTSSCTSBCTSKKDM4E | |
| SCHEMBL7414895 | 0.86 | CTSL (0.47) | CTSLCTSS | |
| SCHEMBL7423676 | 0.83 | CTSL (0.44) | CTSLCTSSCTSBCTSKRAB9A | |
| SCHEMBL7419135 | 0.79 | CTSS (0.45) | CTSLCTSSCTSBCTSK | |
| SCHEMBL7419245 | 0.77 | SIGMAR1 (0.41) | CTSLCTSSCTSBCTSKRAB9A | |
| SCHEMBL7014338 | 0.77 | CTSS (0.44) | CTSLCTSSCTSBCTSKALDH1A1 | |
| SCHEMBL7422431 | 0.76 | CTSS (0.47) | CTSLCTSSCTSBCTSKALDH1A1 | |
| SCHEMBL7021490 | 0.76 | CTSK (0.56) | CTSLCTSSCTSBCTSK | |
| SCHEMBL7021242 | 0.75 | CTSL (0.39) | CTSLCTSSCTSBCTSK | |
| SCHEMBL7417228 | 0.74 | CTSL (0.44) | CTSLCTSSCTSBCTSKATM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1218372-A1 | NOVEL SPIROHETEROCYCLIC COMPOUNDS USEFUL AS REVERSIBLE INHIBITORS OF CYSTEINE PROTEASES | Boehringer Ingelheim Pharmaceuticals, Inc. (US) | 2002-07-03 | — | — | EP | disclosed |
| WO-2001019816-A1 | NOVEL SPIROHETEROCYCLIC COMPOUNDS USEFUL AS REVERSIBLE INHIBITORS OF CYSTEINE PROTEASES | BOEHRINGER INGELHEIM PHARMACEUTICALS, INC. (US) | 2001-03-22 | — | — | WO | disclosed |