Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRM4 | P08173 | 1/20 | 0.45 |
| ▸ | SCN1A | P35498 | 1/20 | 0.44 |
| ▸ | SCN2A | Q99250 | 1/20 | 0.44 |
| ▸ | SCN3A | Q9NY46 | 1/20 | 0.44 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 2/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.41 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | HRH2 | P25021 | 2/20 | 0.40 |
| ▸ | HRH1 | P35367 | 2/20 | 0.40 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.39 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.39 |
| ▸ | P2RY12 | Q9H244 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16244844 | 0.82 | CCR1 (0.49) | CHRM4LMNAPOLBSMN1; SMN2MEN1 | |
| SCHEMBL3039425 | 0.81 | GPR119 (0.53) | PDE4BMEN1KMT2AHRH3GPR119 | |
| SCHEMBL7478597 | 0.80 | MEN1 (0.48) | CHRM4SMN1; SMN2MEN1KMT2AOPRD1 | |
| SCHEMBL15379831 | 0.78 | LMNA (0.49) | LMNAPOLBSMN1; SMN2HRH2HRH1 | |
| SCHEMBL31112160 | 0.77 | HRH2 (0.49) | LMNAPOLBSMN1; SMN2MEN1KMT2A | |
| SCHEMBL7425816 | 0.77 | SMN1; SMN2 (0.45) | CHRM4LMNAPOLBSMN1; SMN2OPRD1 | |
| SCHEMBL21996849 | 0.76 | NAMPT (0.50) | LMNAPOLBSMN1; SMN2L3MBTL1HRH2 | |
| SCHEMBL5743393 | 0.76 | HRH3 (0.52) | HRH3GPR119 | |
| SCHEMBL7485189 | 0.75 | CCR1 (0.45) | MEN1KMT2AOPRD1OPRK1HRH1 | |
| SCHEMBL1006659 | 0.75 | LMNA (0.45) | LMNAPOLBSMN1; SMN2HRH2HRH1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0958280-A1 | ARYLPIPERIDINOPROPANOL AND ARYLPIPERAZINOPROPANOL DERIVATIVES AND PHARMACEUTICALS CONTAINING THE SAME | SUNTORY LIMITED (JP) | 1999-11-24 | — | — | EP | disclosed |
| WO-1999023072-A1 | ARYLPIPERIDINOPROPANOL AND ARYLPIPERAZINOPROPANOL DERIVATIVES AND PHARMACEUTICALS CONTAINING THE SAME | SUNTORY LIMITED (JP) | 1999-05-14 | — | — | WO | disclosed |