Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 1/20 | 0.48 |
| ▸ | BCL2L1 | Q07817 | 1/20 | 0.45 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.45 |
| ▸ | ITGB3 | P05106 | 5/20 | 0.44 |
| ▸ | ITGA2B | P08514 | 5/20 | 0.44 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.44 |
| ▸ | MMP2 | P08253 | 7/20 | 0.43 |
| ▸ | MMP9 | P14780 | 5/20 | 0.43 |
| ▸ | ITGB1 | P05556 | 1/20 | 0.42 |
| ▸ | ITGA5 | P08648 | 1/20 | 0.42 |
| ▸ | ADAMTS5 | Q9UNA0 | 1/20 | 0.41 |
| ▸ | KCNA5 | P22460 | 1/20 | 0.41 |
| ▸ | MMP3 | P08254 | 1/20 | 0.40 |
| ▸ | MMP13 | P45452 | 1/20 | 0.40 |
| ▸ | ADAMTS4 | O75173 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Trifluoroacetic Acid SCHEMBL7413027 | 0.96 | MAPT (0.45) | MAPTBCL2L1MCL1ITGB3ITGA2B | |
| SCHEMBL7413033 | 0.89 | MAPT (0.41) | MAPTBCL2L1MCL1ITGB3ITGA2B | |
| SCHEMBL7417646 | 0.83 | MMP2 (0.56) | ITGB3ITGA2BMMP2MMP9ADAMTS5 | |
| SCHEMBL7418686 | 0.82 | ITGB1 (0.51) | ITGB3ITGA2BITGB1ITGA5 | |
| SCHEMBL7463648 | 0.82 | MAPT (0.46) | MAPTBCL2L1MCL1ITGB3ITGA2B | |
| SCHEMBL7409585 | 0.82 | ITGB3 (0.61) | ITGB3ITGA2BMMP2MMP9KCNA5 | |
| SCHEMBL7409554 | 0.81 | MMP2 (0.61) | ITGB3ITGA2BMMP2MMP9ADAMTS5 | |
| SCHEMBL7696995 | 0.81 | ITGB3 (0.53) | ITGB3ITGA2BMMP2MMP9KCNA5 | |
| SCHEMBL7419820 | 0.80 | ITGB3 (0.48) | ITGB3ITGA2BMMP2MMP9ITGB1 | |
| SCHEMBL7420817 | 0.80 | ITGB3 (0.56) | ITGB3ITGA2BMMP2MMP9KCNA5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6344484-B1 | TREATMENT OF TUMOR GROWTH, METASTASIS, OSTEOPOROSIS, RESTENOSIS, INFLAMMATION, MACULAR DEGENERATION, DIABETIC RETINOPATHY, AND RHEUMATOID ARTHRITIS | 3-DIMENSIONAL PHARMACEUTICALS, INC. | 2002-02-05 | — | — | US | claimed |
| EP-1159262-A1 | TYROSINE ALKOXYGUANIDINES AS INTEGRIN INHIBITORS | 3-DIMENSIONAL PHARMACEUTICALS, INC. (US) | 2001-12-05 | — | — | EP | claimed |
| WO-2000047552-A1 | TYROSINE ALKOXYGUANIDINES AS INTEGRIN INHIBITORS | 3-DIMENSIONAL PHARMACEUTICALS, INC. (US) | 2000-08-17 | — | — | WO | claimed |