SCHEMBL7422293

SCHEMBL7422293

N#Cc1cccc(CN2C[C@H](NC(=O)c3ccccc3)C2=O)c1

nearest known ligand 0.50

Predicted protein targets (top 19)

geneUniProtsupporting neighboursconfidence
BRD4 O60885 1/20 0.50
SIRT2 Q8IXJ6 1/20 0.49
SIRT1 Q96EB6 1/20 0.49
CCKBR P32239 1/20 0.46
FAAH O00519 1/20 0.46
NTRK1 P04629 1/20 0.45
MAOA P21397 1/20 0.44
VNN1 O95497 1/20 0.43
RIPK1 Q13546 4/20 0.42
PTGER4 P35408 1/20 0.42
CHRM3 P20309 1/20 0.42
CCR3 P51677 1/20 0.42
F10 P00742 1/20 0.41
HDAC6 Q9UBN7 2/20 0.41
HDAC1 Q13547 1/20 0.41
HDAC8 Q9BY41 1/20 0.41
ACKR3 P25106 1/20 0.41
SRC P12931 1/20 0.41
RORC P51449 1/20 0.41

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7424674 0.89 HDAC1 (0.52) BRD4SIRT2SIRT1FAAHNTRK1
SCHEMBL7422296 0.82 MAOA (0.49) SIRT2SIRT1FAAHMAOACHRM3
SCHEMBL7421293 0.81 BRD4 (0.47) BRD4SIRT2SIRT1FAAHRIPK1
SCHEMBL7420184 0.81 SRC (0.49) BRD4SIRT2SIRT1RIPK1PTGER4
SCHEMBL7417098 0.81 ROCK2 (0.47) BRD4RIPK1F10HDAC6HDAC1
SCHEMBL2329293 0.80 SIRT2 (0.45) BRD4SIRT2SIRT1FAAHRIPK1
SCHEMBL7423020 0.80 CCR3 (0.46) BRD4RIPK1CHRM3CCR3HDAC6
SCHEMBL7428971 0.80 BRD4 (0.48) BRD4RIPK1CHRM3F10HDAC6
SCHEMBL7418733 0.79 CCKBR (0.52) BRD4CCKBRF10HDAC6HDAC1
SCHEMBL7419869 0.78 MCHR1 (0.49) BRD4CHRM3CCR3F10SRC

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0853618-A4 SUBSTITUTED (SULFINIC ACID, SULFONIC ACID, SULFONYLAMINO OR SULFINYLAMINO) N- (AMINOIMINOMETHYL)PHENYLALKYL]-AZAHETEROCYCLYLAMIDE COMPOUNDS RHONE POULENC RORER PHARMA (US) 2000-03-15 EP disclosed
EP-0853618-A1 SUBSTITUTED (SULFINIC ACID, SULFONIC ACID, SULFONYLAMINO OR SULFINYLAMINO) N- (AMINOIMINOMETHYL)PHENYLALKYL]-AZAHETEROCYCLYLAMIDE COMPOUNDS RHONE-POULENC RORER PHARMACEUTICALS, INC. (US) 1998-07-22 EP disclosed
WO-1996040679-A1 SUBSTITUTED (SULFINIC ACID, SULFONIC ACID, SULFONYLAMINO OR SULFINYLAMINO) N-[(AMINOIMINOMETHYL)PHENYLALKYL]-AZAHETEROCYCLYLAMIDE COMPOUNDS RHÔNE-POULENC RORER PHARMACEUTICALS INC. (US) 1996-12-19 WO disclosed