Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK1 | P28482 | 1/20 | 0.60 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.57 |
| ▸ | HTT | P42858 | 1/20 | 0.57 |
| ▸ | PKM | P14618 | 1/20 | 0.56 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.54 |
| ▸ | ABCC1 | P33527 | 1/20 | 0.54 |
| ▸ | NAMPT | P43490 | 2/20 | 0.52 |
| ▸ | PDE4A | P27815 | 2/20 | 0.48 |
| ▸ | PDE4B | Q07343 | 2/20 | 0.48 |
| ▸ | PDE4C | Q08493 | 2/20 | 0.48 |
| ▸ | PDE4D | Q08499 | 2/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.47 |
| ▸ | LMNA | P02545 | 1/20 | 0.47 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7425093 | 0.82 | PKM (0.66) | SMN1; SMN2HTTPKMABCB1ABCC1 | |
| SCHEMBL7425436 | 0.81 | PKM (0.82) | SMN1; SMN2HTTPKMNAMPTPDE4A | |
| SCHEMBL7422958 | 0.79 | PDE4A (0.69) | ABCB1ABCC1NAMPTPDE4APDE4B | |
| SCHEMBL7428268 | 0.74 | HTT (0.65) | MAPK1SMN1; SMN2HTTPKMPDE4A | |
| SCHEMBL7425706 | 0.73 | SMN1; SMN2 (1.00) | MAPK1SMN1; SMN2HTTPKMALDH1A1 | |
| SCHEMBL11366681 | 0.73 | NAMPT (0.72) | SMN1; SMN2HTTPKMNAMPTALDH1A1 | |
| SCHEMBL7415584 | 0.72 | SMN1; SMN2 (0.78) | MAPK1SMN1; SMN2HTTPKMALDH1A1 | |
| SCHEMBL7425459 | 0.72 | GAA (0.80) | MAPK1SMN1; SMN2HTTALDH1A1KMT2A | |
| SCHEMBL7425971 | 0.72 | KMT2A (0.79) | SMN1; SMN2HTTPKMALDH1A1KMT2A | |
| SCHEMBL29250014 | 0.71 | TP53 (0.67) | SMN1; SMN2PKMNAMPTLMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1996036595-A1 | 3,4-DISUBSTITUTED-PHENYLSULPHONAMIDES AND THEIR THERAPEUTIC USE | CHIROSCIENCE LIMITED (GB) | 1996-11-21 | — | — | WO | disclosed |