Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CFD | P00746 | 2/20 | 0.34 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.31 |
| ▸ | HRH1 | P35367 | 1/20 | 0.31 |
| ▸ | DPP4 | P27487 | 3/20 | 0.30 |
| ▸ | DPP9 | Q86TI2 | 1/20 | 0.30 |
| ▸ | CTSC | P53634 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL742245 | 1.00 | CFD (0.34) | CFDCYP2D6HRH1DPP4DPP9 | |
| SCHEMBL741160 | 0.93 | BTK (0.31) | CFDDPP4CTSC | |
| SCHEMBL741161 | 0.93 | BTK (0.31) | CFDDPP4CTSC | |
| SCHEMBL741416 | 0.91 | CFD (0.36) | CFDCYP2D6HRH1 | |
| SCHEMBL741417 | 0.91 | CFD (0.36) | CFDCYP2D6HRH1 | |
| SCHEMBL740294 | 0.90 | CFD (0.37) | CFDCYP2D6HRH1DPP4CTSC | |
| SCHEMBL742026 | 0.90 | CFD (0.37) | CFDCYP2D6HRH1DPP4CTSC | |
| SCHEMBL2791483 | 0.89 | CNR2 (0.33) | CFDDPP4CTSC | |
| SCHEMBL741797 | 0.89 | LIPG (0.35) | CFDCTSC | |
| SCHEMBL741798 | 0.89 | LIPG (0.35) | CFDCTSC |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8138168-B1 | Renin inhibitors | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2012-03-20 | — | — | US | claimed |
| US-8138168-B1 | Renin inhibitors | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2012-03-20 | — | — | US | disclosed |
| US-8138168-B1 | Renin inhibitors | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2012-03-20 | — | — | US | disclosed |
| US-8138168-B1 | Renin inhibitors | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2012-03-20 | — | — | US | disclosed |