Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.54 |
| ▸ | HPGD | P15428 | 1/20 | 0.54 |
| ▸ | PKN1 | Q16512 | 1/20 | 0.53 |
| ▸ | PKN2 | Q16513 | 1/20 | 0.53 |
| ▸ | DHODH | Q02127 | 10/20 | 0.52 |
| ▸ | PARP1 | P09874 | 7/20 | 0.51 |
| ▸ | CNR2 | P34972 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7475827 | 0.86 | PKN1 (0.57) | KDM4EPKN1PKN2PARP1 | |
| SCHEMBL8952887 | 0.84 | KDM4E (0.62) | KDM4EHPGDDHODHPARP1 | |
| SCHEMBL28267033 | 0.83 | KDM4E (0.61) | KDM4EHPGDDHODHPARP1 | |
| SCHEMBL7427217 | 0.82 | HRH4 (0.56) | KDM4EHPGDPKN1PKN2CNR2 | |
| SCHEMBL27720114 | 0.80 | KDM4E (0.57) | KDM4EHPGDPKN1PKN2DHODH | |
| SCHEMBL7478700 | 0.79 | KDM4E (0.54) | KDM4EHPGDPKN1PKN2DHODH | |
| SCHEMBL311504 | 0.79 | KDM4E (0.56) | KDM4EHPGDDHODHPARP1 | |
| SCHEMBL25782833 | 0.78 | MAOB (0.57) | KDM4EHPGDPKN1PKN2PARP1 | |
| SCHEMBL7484394 | 0.77 | PKN1 (0.60) | KDM4EHPGDPKN1PKN2DHODH | |
| SCHEMBL1298127 | 0.76 | PARP1 (0.73) | KDM4EHPGDDHODHPARP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6316482-B1 | FOR THERAPY AND PROPHYLAXIS OF HYPERTENSION, HEART FAILURE, RENAL INSUFFICIENCY, EDEMA, ASCITES, VASOPRESSIN PARASECRETION SYNDROME, HEPATOCIRRHOSIS, HYPONATREMIA, HYPOKALEMIA, DIABETIC, CIRCULATION DISORDER, CEREBROVASCULAR DISEASE | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 2001-11-13 | — | — | US | disclosed |
| US-6207693-B1 | Benzamide derivatives having a vasopressin antagonistic activity | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 2001-03-27 | — | — | US | disclosed |
| EP-0946519-A1 | BENZAMIDE DERIVATIVES HAVING A VASOPRESSIN ANTAGONISTIC ACTIVITY | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1999-10-06 | — | — | EP | disclosed |
| WO-1998024771-A1 | BENZAMIDE DERIVATIVES HAVING A VASOPRESSIN ANTAGONISTIC ACTIVITY | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1998-06-11 | — | — | WO | disclosed |