Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | APP | P05067 | 5/20 | 0.39 |
| ▸ | ACHE | P22303 | 4/20 | 0.39 |
| ▸ | CTNNB1 | P35222 | 4/20 | 0.39 |
| ▸ | TCF7L2 | Q9NQB0 | 4/20 | 0.39 |
| ▸ | TP53 | P04637 | 2/20 | 0.38 |
| ▸ | PDE3B | Q13370 | 2/20 | 0.38 |
| ▸ | PDE3A | Q14432 | 2/20 | 0.38 |
| ▸ | PDE2A | O00408 | 1/20 | 0.38 |
| ▸ | CCR4 | P51679 | 1/20 | 0.38 |
| ▸ | PDE5A | O76074 | 4/20 | 0.38 |
| ▸ | BCHE | P06276 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | THRB | P10828 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | SLC2A1 | P11166 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7018309 | 0.94 | PDE5A (0.46) | PDE5A | |
| SCHEMBL7016859 | 0.92 | ACHE (0.40) | APPACHECTNNB1TCF7L2TP53 | |
| SCHEMBL7014745 | 0.91 | APP (0.41) | APPACHECTNNB1TCF7L2TP53 | |
| SCHEMBL7014936 | 0.90 | CTNNB1 (0.47) | CTNNB1TCF7L2 | |
| SCHEMBL7422776 | 0.90 | CCR4 (0.42) | APPACHETP53CCR4PDE5A | |
| SCHEMBL7016913 | 0.90 | APP (0.40) | APPACHECTNNB1TCF7L2TP53 | |
| SCHEMBL8169893 | 0.90 | ALDH1A1 (0.47) | CTNNB1TCF7L2TP53PDE3BPDE3A | |
| SCHEMBL7020185 | 0.89 | CTNNB1 (0.39) | CTNNB1TCF7L2PDE2APDE5A | |
| SCHEMBL7018883 | 0.89 | CTNNB1 (0.42) | CTNNB1TCF7L2PDE5A | |
| SCHEMBL8180973 | 0.87 | PDE4A (0.46) | APPACHECTNNB1TCF7L2TP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0934321-B1 | THIENOPYRIMIDINE WITH PHOSPHODIESTERASE V INHIBITING EFFECT | MERCK PATENT GMBH (DE) | 2003-08-06 | — | — | EP | disclosed |