Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | F2RL3 | Q96RI0 | 3/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | RECQL | P46063 | 1/20 | 0.41 |
| ▸ | PDE4A | P27815 | 8/20 | 0.41 |
| ▸ | PDE4B | Q07343 | 8/20 | 0.41 |
| ▸ | PDE4C | Q08493 | 8/20 | 0.41 |
| ▸ | PDE4D | Q08499 | 8/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.38 |
| ▸ | MAPT | P10636 | 2/20 | 0.38 |
| ▸ | PKM | P14618 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.38 |
| ▸ | PIM1 | P11309 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3610073 | 0.83 | LMNA (0.57) | F2RL3LMNARECQLPDE4APDE4B | |
| SCHEMBL7423948 | 0.83 | PDE4D (0.48) | LMNARECQLPDE4APDE4BPDE4C | |
| SCHEMBL16708177 | 0.78 | F2RL3 (0.45) | F2RL3LMNARECQLPDE4APDE4B | |
| SCHEMBL16345218 | 0.76 | LMNA (0.43) | F2RL3LMNARECQLALDH1A1MAPT | |
| SCHEMBL7427719 | 0.76 | LMNA (0.68) | LMNARECQLCYP1A2ALDH1A1MAPT | |
| SCHEMBL7049405 | 0.74 | PDE4A (0.59) | F2RL3LMNARECQLPDE4APDE4B | |
| SCHEMBL31482723 | 0.73 | PDE4D (0.47) | F2RL3PDE4BPDE4DCYP1A2ALDH1A1 | |
| SCHEMBL7425562 | 0.72 | ALDH1A1 (0.43) | LMNAPDE4APDE4BPDE4CPDE4D | |
| SCHEMBL7053222 | 0.72 | F2RL3 (0.42) | F2RL3LMNARECQLPDE4APDE4B | |
| SCHEMBL1368772 | 0.71 | CA12 (0.47) | F2RL3ALDH1A1MAPTHPGDHSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1054884-A1 | BENZOFURAN-4-CARBOXAMIDES AND THEIR THERAPEUTIC USE | Darwin Discovery Limited (GB) | 2000-11-29 | — | — | EP | disclosed |
| US-6066657-A | Benzofuran-4-carboxamides and their therapeutic use | DARWIN DISCOVERY, LTD. (GB) | 2000-05-23 | — | — | US | disclosed |
| WO-1999040085-A1 | BENZOFURAN-4-CARBOXAMIDES AND THEIR THERAPEUTIC USE | DARWIN DISCOVERY LIMITED (GB) | 1999-08-12 | — | — | WO | disclosed |