Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4D | Q08499 | 15/20 | 0.48 |
| ▸ | PDE4B | Q07343 | 12/20 | 0.48 |
| ▸ | PDE4A | P27815 | 11/20 | 0.48 |
| ▸ | PDE4C | Q08493 | 11/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | CA12 | O43570 | 1/20 | 0.40 |
| ▸ | CA1 | P00915 | 1/20 | 0.40 |
| ▸ | CA2 | P00918 | 1/20 | 0.40 |
| ▸ | CA3 | P07451 | 1/20 | 0.40 |
| ▸ | CA4 | P22748 | 1/20 | 0.40 |
| ▸ | CA6 | P23280 | 1/20 | 0.40 |
| ▸ | CA5A | P35218 | 1/20 | 0.40 |
| ▸ | CA7 | P43166 | 1/20 | 0.40 |
| ▸ | CA9 | Q16790 | 1/20 | 0.40 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.40 |
| ▸ | CA5B | Q9Y2D0 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | RECQL | P46063 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7056726 | 0.84 | PDE4A (0.62) | PDE4DPDE4BPDE4APDE4CKDM4E | |
| SCHEMBL7422796 | 0.83 | F2RL3 (0.44) | PDE4DPDE4BPDE4APDE4CKDM4E | |
| SCHEMBL7051399 | 0.81 | PDE4A (0.55) | PDE4DPDE4BPDE4APDE4CKDM4E | |
| SCHEMBL6839328 | 0.78 | SMN1; SMN2 (0.62) | PDE4DPDE4BPDE4APDE4CKDM4E | |
| SCHEMBL7425562 | 0.78 | ALDH1A1 (0.43) | PDE4DPDE4BPDE4APDE4CKDM4E | |
| SCHEMBL6839386 | 0.77 | PDE4A (0.48) | PDE4DPDE4BPDE4APDE4C | |
| SCHEMBL7053234 | 0.77 | PDE4A (0.50) | PDE4DPDE4BPDE4APDE4CKDM4E | |
| SCHEMBL6947312 | 0.77 | PDE4D (0.55) | PDE4DPDE4BPDE4APDE4CKDM4E | |
| SCHEMBL7053236 | 0.77 | PDE4A (0.50) | PDE4DPDE4BPDE4APDE4CKDM4E | |
| SCHEMBL7053230 | 0.77 | PDE4A (0.50) | PDE4DPDE4BPDE4APDE4CKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1054884-A1 | BENZOFURAN-4-CARBOXAMIDES AND THEIR THERAPEUTIC USE | Darwin Discovery Limited (GB) | 2000-11-29 | — | — | EP | disclosed |
| US-6066657-A | Benzofuran-4-carboxamides and their therapeutic use | DARWIN DISCOVERY, LTD. (GB) | 2000-05-23 | — | — | US | disclosed |
| WO-1999040085-A1 | BENZOFURAN-4-CARBOXAMIDES AND THEIR THERAPEUTIC USE | DARWIN DISCOVERY LIMITED (GB) | 1999-08-12 | — | — | WO | disclosed |