Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTSS | P25774 | 12/20 | 0.38 |
| ▸ | CTSL | P07711 | 10/20 | 0.38 |
| ▸ | CTSB | P07858 | 3/20 | 0.37 |
| ▸ | CTSK | P43235 | 1/20 | 0.37 |
| ▸ | CTSC | P53634 | 1/20 | 0.30 |
| ▸ | JAK2 | O60674 | 1/20 | 0.30 |
| ▸ | JAK1 | P23458 | 1/20 | 0.30 |
| ▸ | ACHE | P22303 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7417521 | 0.84 | CTSS (0.38) | CTSSCTSLCTSBCTSK | |
| SCHEMBL5357493 | 0.79 | CTSS (0.53) | CTSSCTSLCTSBCTSK | |
| SCHEMBL5363187 | 0.78 | CTSS (0.39) | CTSSCTSLCTSBCTSK | |
| SCHEMBL7012870 | 0.75 | CTSS (0.41) | CTSSCTSLCTSBCTSKJAK2 | |
| SCHEMBL7008282 | 0.73 | CTSL (0.40) | CTSSCTSLCTSBCTSK | |
| SCHEMBL7004000 | 0.73 | CTSS (0.50) | CTSSCTSLCTSBCTSK | |
| SCHEMBL7007715 | 0.71 | CTSS (0.39) | CTSSCTSLCTSBCTSKCTSC | |
| SCHEMBL7010006 | 0.70 | CTSS (0.49) | CTSSCTSLCTSBCTSK | |
| SCHEMBL7415395 | 0.70 | CTSS (0.38) | CTSSCTSLCTSBCTSK | |
| SCHEMBL7418241 | 0.70 | CTSL (0.34) | CTSSCTSLCTSBCTSK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1218372-A1 | NOVEL SPIROHETEROCYCLIC COMPOUNDS USEFUL AS REVERSIBLE INHIBITORS OF CYSTEINE PROTEASES | Boehringer Ingelheim Pharmaceuticals, Inc. (US) | 2002-07-03 | — | — | EP | disclosed |
| WO-2001019816-A1 | NOVEL SPIROHETEROCYCLIC COMPOUNDS USEFUL AS REVERSIBLE INHIBITORS OF CYSTEINE PROTEASES | BOEHRINGER INGELHEIM PHARMACEUTICALS, INC. (US) | 2001-03-22 | — | — | WO | disclosed |