Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACHE | P22303 | 9/20 | 0.57 |
| ▸ | BCHE | P06276 | 6/20 | 0.57 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.57 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.57 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.54 |
| ▸ | TTR | P02766 | 1/20 | 0.54 |
| ▸ | GLA | P06280 | 1/20 | 0.54 |
| ▸ | POLB | P06746 | 1/20 | 0.54 |
| ▸ | GAA | P10253 | 1/20 | 0.54 |
| ▸ | MAPT | P10636 | 1/20 | 0.54 |
| ▸ | RAD52 | P43351 | 1/20 | 0.54 |
| ▸ | PDE5A | O76074 | 3/20 | 0.54 |
| ▸ | APP | P05067 | 6/20 | 0.53 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.52 |
| ▸ | THRB | P10828 | 1/20 | 0.52 |
| ▸ | MEN1 | O00255 | 1/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.52 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.48 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.48 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7416586 | 0.86 | EGFR (0.52) | CYP1A2CYP3A4POLBGAAMAPT | |
| SCHEMBL7418464 | 0.86 | APP (0.53) | CYP1A2CYP3A4POLBGAAMAPT | |
| Hydrochloric Acid SCHEMBL7423114 | 0.85 | EGFR (0.51) | CYP1A2CYP3A4POLBGAAMAPT | |
| SCHEMBL7028354 | 0.85 | KMT2A (0.60) | ACHEBCHEKDM4EPOLBMAPT | |
| SCHEMBL7423097 | 0.82 | POLB (0.48) | ACHEBCHEPOLBRAD52PDE5A | |
| SCHEMBL7420540 | 0.82 | POLB (0.50) | ACHEBCHEPOLBRAD52PDE5A | |
| SCHEMBL7420650 | 0.81 | PDE5A (0.50) | ACHEBCHECYP1A2CYP3A4KDM4E | |
| SCHEMBL7418635 | 0.81 | POLB (0.51) | KDM4EPOLBMAPTRAD52PDE5A | |
| SCHEMBL7421877 | 0.80 | TACR3 (0.51) | KDM4EPOLBMAPTRAD52PDE5A | |
| SCHEMBL8444030 | 0.79 | ALDH1A1 (0.50) | CYP1A2CYP3A4KDM4EGLAPOLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6008226-A | AN ENZYME INHIBITOR OF C-GMP-PHOSPHODIESTERASE FOR TREATING HEART FAILURE, HYPERTENSION, REVERSING OR REDUCING NITRATE-INDUCED TOLERANCE AND ANGINA PECTORIS, CONGESTIVE HEART DISEASE AND MYOCARDIAL INFARCTION | SANOFI-SYNTHELABO (FR) | 1999-12-28 | — | — | US | disclosed |
| US-5852035-A | Method for inhibiting neoplastic cells and related conditions by exposure to substituted N- arylmethyl and heterocyclmethyl-1H-pyrazolo (3,4-B) quinolin-4-amines | CELL PATHWAYS, INC. (US) | 1998-12-22 | — | — | US | disclosed |
| US-5843956-A | Substituted N-arylmethyl and heterocyclylmethyl-1H-pyrazolo (3,4-b) quinolin-4-amines and compositions and methods of use thereof | SANOFI (FR) | 1998-12-01 | — | — | US | disclosed |
| US-5614530-A | GMP PHOSPHODIESTERASE INHIBITOR, HYPOTENSIVE | STERLING WINTHROP INC. (US) | 1997-03-25 | — | — | US | disclosed |
| WO-1996028159-A1 | SUBSTITUTED N-ARYLMETHYL AND HETEROCYCLYLMETHYL-1H-PYRAZOLO[3,4-b]QUINOLIN-4-AMINES AND COMPOSITIONS AND METHODS OF USE THEREOF | SANOFI WINTHROP, INC. (US) | 1996-09-19 | — | — | WO | disclosed |