Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRNA7 | P36544 | 1/20 | 0.65 |
| ▸ | MEN1 | O00255 | 1/20 | 0.57 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.57 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.47 |
| ▸ | SLC6A4 | P31645 | 4/20 | 0.46 |
| ▸ | SLC6A3 | Q01959 | 4/20 | 0.46 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.46 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.46 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.46 |
| ▸ | TSHR | P16473 | 1/20 | 0.46 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.46 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.46 |
| ▸ | SLC22A1 | O15245 | 1/20 | 0.46 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.46 |
| ▸ | HTR1A | P08908 | 1/20 | 0.46 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.46 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.46 |
| ▸ | DRD1 | P21728 | 1/20 | 0.46 |
| ▸ | TBXA2R | P21731 | 1/20 | 0.46 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4728006 | 0.78 | CHRNA7 (0.77) | CHRNA7MEN1KMT2ASIGMAR1SLC6A4 | |
| SCHEMBL8097776 | 0.76 | CHRNA7 (0.79) | CHRNA7MEN1KMT2ASIGMAR1SLC6A4 | |
| SCHEMBL10552209 | 0.76 | CHRNA7 (0.66) | CHRNA7MEN1KMT2ASIGMAR1SLC6A4 | |
| SCHEMBL9590780 | 0.75 | HTR1A (0.42) | CHRNA7KMT2ASIGMAR1SLC6A4SLC6A3 | |
| SCHEMBL8892312 | 0.72 | CHRNA7 (0.58) | CHRNA7MEN1KMT2ASIGMAR1SLC6A4 | |
| SCHEMBL8893433 | 0.72 | CHRNA7 (0.55) | CHRNA7MEN1KMT2ASIGMAR1SLC6A4 | |
| SCHEMBL7418255 | 0.72 | SIGMAR1 (0.71) | MEN1KMT2ASIGMAR1SLC6A4SLC6A3 | |
| SCHEMBL10357800 | 0.71 | SIGMAR1 (0.81) | MEN1KMT2ASIGMAR1SLC6A4SLC6A3 | |
| SCHEMBL4669319 | 0.71 | CYP2D6 (0.68) | CHRNA7MEN1KMT2ASLC6A4SLC6A3 | |
| SCHEMBL8892798 | 0.71 | CHRNA7 (0.60) | CHRNA7MEN1KMT2ASIGMAR1SLC6A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5276035-A | Central nervous system disorders; Parkinson's disease; antidepressant and dopaminergic agent | NOVO NORDISK A/S (DK) | 1994-01-04 | — | — | US | disclosed |
| EP-0541617-A1 | 1,4-DISUBSTITUTED PIPERAZINES. | NOVO NORDISK AS (DK) | 1993-05-19 | — | — | EP | disclosed |
| WO-1992001679-A1 | 1,4-DISUBSTITUTED PIPERAZINES | NOVO NORDISK A/S (DK) | 1992-02-06 | — | — | WO | disclosed |