Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.61 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.58 |
| ▸ | HTT | P42858 | 1/20 | 0.58 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.52 |
| ▸ | HPGD | P15428 | 5/20 | 0.51 |
| ▸ | MEN1 | O00255 | 2/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.51 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.51 |
| ▸ | PKM | P14618 | 2/20 | 0.50 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.49 |
| ▸ | NPC1 | O15118 | 1/20 | 0.49 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.48 |
| ▸ | POLB | P06746 | 1/20 | 0.48 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.48 |
| ▸ | LMNA | P02545 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7888362 | 0.89 | SMN1; SMN2 (0.61) | SMN1; SMN2ALDH1A1HTTHSD17B10HPGD | |
| SCHEMBL7429168 | 0.87 | SMN1; SMN2 (0.59) | SMN1; SMN2ALDH1A1HTTHSD17B10HPGD | |
| SCHEMBL7421896 | 0.87 | SMN1; SMN2 (0.59) | SMN1; SMN2ALDH1A1HTTHSD17B10HPGD | |
| SCHEMBL7890880 | 0.87 | ALDH1A1 (0.58) | SMN1; SMN2ALDH1A1HTTHSD17B10HPGD | |
| SCHEMBL7889258 | 0.85 | SMN1; SMN2 (0.57) | SMN1; SMN2ALDH1A1HTTHSD17B10HPGD | |
| SCHEMBL7422482 | 0.84 | SMN1; SMN2 (0.40) | SMN1; SMN2ALDH1A1HTTHSD17B10HPGD | |
| SCHEMBL8209522 | 0.81 | TDP1 (0.60) | SMN1; SMN2ALDH1A1HSD17B10HPGDMEN1 | |
| SCHEMBL7893101 | 0.80 | ALDH1A1 (0.56) | SMN1; SMN2ALDH1A1MEN1KMT2ATDP1 | |
| SCHEMBL7889273 | 0.79 | FAAH (0.48) | ALDH1A1HPGDKMT2ACHRM4KDM4E | |
| SCHEMBL7880879 | 0.79 | NCEH1 (0.48) | SMN1; SMN2ALDH1A1HSD17B10HPGDNPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0934301-B1 | AMINOTHIOPHENE CARBOXYLIC ACID AMIDES AND THE USE THEREOF AS PHOSPHODIESTERASE INHIBITORS | MERCK PATENT GMBH (DE) | 2001-06-20 | — | — | EP | disclosed |
| EP-0934301-A1 | AMINOTHIOPHENE CARBOXYLIC ACID AMIDES AND THE USE THEREOF AS PHOSPHODIESTERASE INHIBITORS | MERCK PATENT GmbH (DE) | 1999-08-11 | — | — | EP | disclosed |
| WO-1998016521-A1 | AMINOTHIOPHENE CARBOXYLIC ACID AMIDES AND THE USE THEREOF AS PHOSPHODIESTERASE INHIBITORS | MERCK PATENT GMBH (DE) | 1998-04-23 | — | — | WO | disclosed |