Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DPP4 | P27487 | 1/20 | 0.44 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.43 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 2/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | HPGD | P15428 | 1/20 | 0.42 |
| ▸ | HSD11B1 | P28845 | 2/20 | 0.41 |
| ▸ | ALOX5AP | P20292 | 9/20 | 0.38 |
| ▸ | MEN1 | O00255 | 2/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.38 |
| ▸ | TP53 | P04637 | 1/20 | 0.37 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7416251 | 0.81 | ALDH1A1 (0.54) | DPP4ALDH1A1KDM4EMAPK1HSD17B10 | |
| SCHEMBL7423051 | 0.80 | DPP4 (0.45) | DPP4ALDH1A1KDM4EMAPK1HSD17B10 | |
| SCHEMBL7422984 | 0.78 | DPP4 (0.47) | DPP4ALDH1A1KDM4EMAPK1HSD17B10 | |
| SCHEMBL7424979 | 0.74 | FABP4 (0.51) | DPP4ALDH1A1KDM4EHSD17B10HPGD | |
| SCHEMBL7467571 | 0.74 | DPP4 (0.44) | DPP4ALDH1A1LMNAALOX5APMEN1 | |
| SCHEMBL7470778 | 0.71 | DPP4 (0.46) | DPP4ALDH1A1KDM4EMAPK1MAPT | |
| SCHEMBL7423106 | 0.68 | ALOX5AP (0.42) | DPP4KCNH2ALDH1A1KDM4EMAPT | |
| SCHEMBL7428288 | 0.67 | ALOX5AP (0.47) | DPP4KCNH2ALDH1A1KDM4EHTT | |
| SCHEMBL10911638 | 0.67 | TP53 (0.52) | ALDH1A1KDM4EMAPK1HSD17B10HTT | |
| SCHEMBL7371677 | 0.67 | ALDH1A1 (0.45) | DPP4ALDH1A1KDM4EMAPK1HSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0820441-B1 | INDOLE DERIVATIVES AS cGMP-PDE INHIBITORS | FUJISAWA PHARMACEUTICAL CO (JP) | 2002-06-26 | — | — | EP | disclosed |
| US-6358992-B1 | Method of inhibiting neoplastic cells with indole derivatives | CELL PATHWAYS, INC. | 2002-03-19 | — | — | US | disclosed |
| US-6069156-A | Indole derivatives as cGMP-PDE inhibitors | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 2000-05-30 | — | — | US | disclosed |
| EP-0820441-A1 | INDOLE DERIVATIVES AS cGMP-PDE INHIBITORS | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1998-01-28 | — | — | EP | disclosed |
| WO-1996032379-A1 | INDOLE DERIVATIVES AS cGMP-PDE INHIBITORS | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1996-10-17 | — | — | WO | disclosed |