Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 4/20 | 0.49 |
| ▸ | RAB9A | P51151 | 2/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.49 |
| ▸ | NPC1 | O15118 | 1/20 | 0.49 |
| ▸ | HTT | P42858 | 2/20 | 0.43 |
| ▸ | MEN1 | O00255 | 5/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.41 |
| ▸ | MAPT | P10636 | 3/20 | 0.41 |
| ▸ | THRB | P10828 | 1/20 | 0.41 |
| ▸ | CCR5 | P51681 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 3/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.39 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.39 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.39 |
| ▸ | GCGR | P47871 | 1/20 | 0.39 |
| ▸ | GIPR | P48546 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7426638 | 0.88 | ALDH1A1 (0.43) | LMNAMEN1KMT2AMAPTGAA | |
| SCHEMBL7425533 | 0.88 | TRPV1 (0.53) | RAB9ANPC1MEN1KMT2APOLB | |
| SCHEMBL7427033 | 0.82 | GRIA2 (0.43) | RAB9ASMN1; SMN2NPC1MEN1KMT2A | |
| SCHEMBL7426467 | 0.82 | GRIA2 (0.43) | RAB9ASMN1; SMN2NPC1MEN1KMT2A | |
| SCHEMBL7425045 | 0.82 | TAS1R3 (0.48) | LMNASMN1; SMN2HTTMEN1KMT2A | |
| SCHEMBL7423336 | 0.79 | PARP10 (0.46) | — | |
| SCHEMBL7424796 | 0.78 | HPGD (0.38) | MEN1KMT2A | |
| SCHEMBL7421295 | 0.77 | PPARG (0.41) | LMNARAB9ASMN1; SMN2NPC1MEN1 | |
| SCHEMBL7418698 | 0.77 | MCHR1 (0.41) | SMN1; SMN2HDAC1HDAC6ALDH1A1 | |
| SCHEMBL7417897 | 0.76 | FOLH1 (0.45) | MEN1KMT2AKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2002039997-A2 | ACE-2 MODULATING COMPOUNDS AND USE THEREOF | MILLENNIUM PHARMACEUTICALS, INC. (US) | 2002-05-23 | — | — | WO | claimed |
| WO-2002039997-A2 | ACE-2 MODULATING COMPOUNDS AND USE THEREOF | MILLENNIUM PHARMACEUTICALS, INC. (US) | 2002-05-23 | — | — | WO | disclosed |