Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGES | O14684 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 6/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
| ▸ | TNF | P01375 | 2/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | NOD2 | Q9HC29 | 1/20 | 0.37 |
| ▸ | NOD1 | Q9Y239 | 1/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.37 |
| ▸ | RXFP1 | Q9HBX9 | 3/20 | 0.37 |
| ▸ | TP53 | P04637 | 2/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | EGLN3 | Q9H6Z9 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7471782 | 0.88 | PTGES (0.46) | PTGESMAPTALDH1A1HPGDTNF | |
| SCHEMBL7427942 | 0.87 | PTGES (0.43) | PTGESMAPTALDH1A1HPGDTNF | |
| SCHEMBL7417850 | 0.84 | L3MBTL1 (0.40) | PTGESMAPTALDH1A1TNFKDM4E | |
| SCHEMBL7421254 | 0.83 | PTGES (0.41) | PTGESMAPTALDH1A1HPGDTNF | |
| SCHEMBL7420327 | 0.83 | ALOX5AP (0.46) | TNFLMNAKDM4ENOD2NOD1 | |
| SCHEMBL3842264 | 0.83 | CNR2 (0.47) | MAPTALDH1A1TNFKDM4ENOD2 | |
| SCHEMBL7427533 | 0.83 | ALOX5AP (0.46) | PTGESALDH1A1L3MBTL1RXFP1TP53 | |
| Hydrochloric Acid SCHEMBL7477963 | 0.83 | L3MBTL1 (0.39) | PTGESMAPTALDH1A1TNFKDM4E | |
| SCHEMBL7425401 | 0.82 | MAPT (0.43) | MAPTALDH1A1HPGDLMNAKDM4E | |
| SCHEMBL7428111 | 0.82 | HDAC8 (0.44) | PTGESRXFP1TP53EGLN3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0820441-B1 | INDOLE DERIVATIVES AS cGMP-PDE INHIBITORS | FUJISAWA PHARMACEUTICAL CO (JP) | 2002-06-26 | — | — | EP | disclosed |
| US-6358992-B1 | Method of inhibiting neoplastic cells with indole derivatives | CELL PATHWAYS, INC. | 2002-03-19 | — | — | US | disclosed |
| US-6069156-A | Indole derivatives as cGMP-PDE inhibitors | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 2000-05-30 | — | — | US | disclosed |
| WO-1996032379-A1 | INDOLE DERIVATIVES AS cGMP-PDE INHIBITORS | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1996-10-17 | — | — | WO | disclosed |