Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ITGB3 | P05106 | 6/20 | 0.41 |
| ▸ | ITGA2B | P08514 | 6/20 | 0.41 |
| ▸ | PPARA | Q07869 | 10/20 | 0.39 |
| ▸ | PPARG | P37231 | 5/20 | 0.39 |
| ▸ | PPARD | Q03181 | 4/20 | 0.39 |
| ▸ | S1PR4 | O95977 | 2/20 | 0.37 |
| ▸ | S1PR1 | P21453 | 2/20 | 0.37 |
| ▸ | S1PR3 | Q99500 | 2/20 | 0.37 |
| ▸ | S1PR5 | Q9H228 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9308843 | 0.86 | ITGB3 (0.58) | ITGB3ITGA2BPPARAPPARGPPARD | |
| SCHEMBL22804109 | 0.81 | SLC7A5 (0.42) | — | |
| SCHEMBL28233244 | 0.81 | CYP1A2 (0.41) | PPARAPPARG | |
| SCHEMBL7106924 | 0.80 | ITGB1 (0.34) | ITGB3PPARA | |
| SCHEMBL7299550 | 0.78 | PPARA (0.40) | PPARAPPARGS1PR4S1PR1S1PR3 | |
| SCHEMBL7110636 | 0.77 | LTB4R (0.52) | — | |
| SCHEMBL7299078 | 0.76 | PPARD (0.39) | PPARAPPARGPPARD | |
| SCHEMBL7292750 | 0.75 | ITGB3 (0.42) | ITGB3ITGA2BPPARAPPARGS1PR4 | |
| SCHEMBL7393691 | 0.72 | ITGB3 (0.60) | ITGB3ITGA2BPPARG | |
| SCHEMBL11686976 | 0.72 | SMN1; SMN2 (0.46) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0528586-B1 | Inhibiting osteoclast-mediated bone resorption using aminoalkyl-substituted phenyl derivatives | MERCK & CO INC (US) | 1995-02-22 | — | — | EP | disclosed |
| US-5217994-A | METHOD OF INHIBITING OSTEOCLAST-MEDIATED BONE RESORPTION BY ADMINISTRATION OF AMINOALKYL-SUBSTITUTED PHENYL DERIVATIVES | MERCK & CO., INC. (US) | 1993-06-08 | — | — | US | disclosed |
| US-5204350-A | Treating osteoporosis | MERCK & CO., INC. (US) | 1993-04-20 | — | — | US | disclosed |
| EP-0528587-A1 | Inhibiting osteoclast-mediated bone resorption using substituted phenyl derivatives | MERCK & CO. INC. (US) | 1993-02-24 | — | — | EP | disclosed |
| EP-0528586-A1 | Inhibiting osteoclast-mediated bone resorption using aminoalkyl-substituted phenyl derivatives | MERCK & CO. INC. (US) | 1993-02-24 | — | — | EP | disclosed |