⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21479447 | 0.93 | ALOX15 (0.40) | — | |
| SCHEMBL9948370 | 0.87 | ALOX15 (0.36) | — | |
| Formic Acid SCHEMBL27997365 | 0.87 | TRIM24 (0.39) | — | |
| SCHEMBL30701903 | 0.84 | CES1 (0.39) | — | |
| SCHEMBL20206843 | 0.84 | CYP1A2 (0.52) | — | |
| SCHEMBL7255805 | 0.84 | CYP2A6 (0.45) | — | |
| SCHEMBL9948344 | 0.82 | CCR1 (0.41) | — | |
| SCHEMBL27027257 | 0.80 | NOS3 (0.38) | — | |
| SCHEMBL27027264 | 0.79 | ALDH1A1 (0.46) | — | |
| SCHEMBL27027261 | 0.79 | ALDH1A1 (0.46) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 28 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11065235-B2 | Substituted methanopyrido [2, 1-a] isoindolones as mAChR modulators for treating various associated pathophysiological conditions and process for preparation thereof | COUNCIL OF SCIENTIFIC & INDUSTRIAL RESEARCH (IN) | 2021-07-20 | — | — | US | claimed |
| CN-116082328-B | Imidazole compound and organic electroluminescent device thereof | 长春海谱润斯科技股份有限公司 | 2025-05-27 | — | — | CN | disclosed |
| CN-115974806-B | Heterocyclic compound and organic electroluminescent device thereof | 长春海谱润斯科技股份有限公司 | 2024-09-27 | — | — | CN | disclosed |
| CN-116156921-A | Organic electroluminescent device | 长春海谱润斯科技股份有限公司 | 2023-05-23 | — | — | CN | disclosed |
| CN-116082328-A | Imidazole compound and organic electroluminescent device thereof | 长春海谱润斯科技股份有限公司 | 2023-05-09 | — | — | CN | disclosed |
| CN-109071446-B | Organic reaction in aqueous solution in the presence of hydroxyalkyl (alkyl) cellulose or alkylcellulose | 艾伯维德国有限责任两合公司 | 2022-06-21 | — | — | CN | disclosed |
| US-11065235-B2 | Substituted methanopyrido [2, 1-a] isoindolones as mAChR modulators for treating various associated pathophysiological conditions and process for preparation thereof | COUNCIL OF SCIENTIFIC & INDUSTRIAL RESEARCH (IN) | 2021-07-20 | — | — | US | disclosed |
| US-11065235-B2 | Substituted methanopyrido [2, 1-a] isoindolones as mAChR modulators for treating various associated pathophysiological conditions and process for preparation thereof | COUNCIL OF SCIENTIFIC & INDUSTRIAL RESEARCH (IN) | 2021-07-20 | — | — | US | disclosed |
| US-11065235-B2 | Substituted methanopyrido [2, 1-a] isoindolones as mAChR modulators for treating various associated pathophysiological conditions and process for preparation thereof | COUNCIL OF SCIENTIFIC & INDUSTRIAL RESEARCH (IN) | 2021-07-20 | — | — | US | disclosed |
| EP-3625232-B1 | SUBSTITUTED METHANOPYRIDO [2, 1-A]ISOINDOLONES AS MACHR MODULATORS FOR TREATING VARIOUS ASSOCIATED PATHOPHYSIOLOGICAL CONDITIONS AND PROCESS FOR PREPARATION THEREOF | COUNCIL SCIENT IND RES (IN) | 2021-06-23 | — | — | EP | disclosed |
| EP-3221312-A2 | SUBSTITUTED BRIDGED UREA ANALOGS AS SIRTUIN MODULATORS | Glaxosmithkline LLC (US) | 2017-09-27 | — | — | EP | disclosed |
| EP-3157931-A1 | CRYSTALLINE FORMS OF (2R,5S,13AR)-8-HYDROXY-7,9-DIOXO-N-(2,4,6-TRIFLUOROBENZYL)-2,3,4,5,7,9,13,13A-OCTAHYDRO-2,5-METHANOPYRIDO [1',2':4,5]PYRAZINO [2,1-B][1,3]OXAZEPINE-10-CARBOXAMIDE | Gilead Sciences, Inc. (US) | 2017-04-26 | — | — | EP | disclosed |
| EP-3157932-A1 | SODIUM (2R, 5S, 13AR) -7, 9-DIOXO-10- ( (2,4,6-TRIFLUOROBENZYL) CARBAMOYL) -2, 3, 4, 5, 7, 9, 13, 13A-OCTAHYDRO-2, 5-METHANOPYRIDO [1',2' : 4.5]PYRAZINO [2, 1-B]OXAZEPIN-8-OLATE | Gilead Sciences, Inc. (US) | 2017-04-26 | — | — | EP | disclosed |
| WO-2016079709-A1 | SUBSTITUTED BRIDGED UREA ANALOGS AS SIRTUIN MODULATORS | GLAXOSMITHKLINE INTELLECTUAL PROPERTY (NO.2) LIMITED (GB) | 2016-05-26 | — | — | WO | disclosed |
| WO-2016081692-A2 | SUBSTITUTED BRIDGED UREA ANALOGS AS SIRTUIN MODULATORS | GLAXOSMITHKLINE LLC (US) | 2016-05-26 | — | — | WO | disclosed |
| WO-2015196116-A1 | SODIUM (2R, 5S, 13AR) -7, 9-DIOXO-10- ( (2,4,6-TRIFLUOROBENZYL) CARBAMOYL) -2, 3, 4, 5, 7, 9, 13, 13A-OCTAHYDRO-2, 5-METHANOPYRIDO [1',2' : 4.5] PYRAZINO [2, 1-B] OXAZEPIN-8-OLATE | GILEAD SCIENCES, INC. (US) | 2015-12-23 | — | — | WO | disclosed |
| WO-2015196137-A1 | CRYSTALLINE FORMS OF (2R,5S,13AR)-8-HYDROXY-7,9-DIOXO-N-(2,4,6-TRIFLUOROBENZYL)-2,3,4,5,7,9,13,13A-OCTAHYDRO-2,5-METHANOPYRIDO [1',2':4,5] PYRAZINO [2,1-B] [1,3] OXAZEPINE-10-CARBOXAMIDE | GILEAD SCIENCES, INC. (US) | 2015-12-23 | — | — | WO | disclosed |
| CN-101233148-A | Macrocyclic peptides as HCV NS3 protease inhibitors | MERCK & CO INC (US) | 2008-07-30 | — | — | CN | disclosed |
| EP-1161434-A1 | PYRIDOPYRANOAZEPINE DERIVATIVES, PREPARATION AND THERAPEUTIC USE | SANOFI-SYNTHELABO (FR) | 2001-12-12 | — | — | EP | disclosed |
| WO-2000053608-A1 | PYRIDOPYRANOAZEPINE DERIVATIVES, PREPARATION AND THERAPEUTIC USE | SANOFI-SYNTHELABO (FR) | 2000-09-14 | — | — | WO | disclosed |