Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP2A6 | P11509 | 1/20 | 0.45 |
| ▸ | DRD2 | P14416 | 3/20 | 0.39 |
| ▸ | DRD3 | P35462 | 2/20 | 0.39 |
| ▸ | DRD1 | P21728 | 1/20 | 0.39 |
| ▸ | DRD4 | P21917 | 1/20 | 0.39 |
| ▸ | DRD5 | P21918 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | GRIN1 | Q05586 | 6/20 | 0.38 |
| ▸ | GRIN2B | Q13224 | 6/20 | 0.38 |
| ▸ | GRIN2D | O15399 | 2/20 | 0.38 |
| ▸ | GRIN3B | O60391 | 2/20 | 0.38 |
| ▸ | GRIN2A | Q12879 | 2/20 | 0.38 |
| ▸ | GRIN2C | Q14957 | 2/20 | 0.38 |
| ▸ | GRIN3A | Q8TCU5 | 2/20 | 0.38 |
| ▸ | METAP2 | P50579 | 1/20 | 0.37 |
| ▸ | HTR2C | P28335 | 2/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.36 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.36 |
| ▸ | HTR1A | P08908 | 1/20 | 0.36 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21479447 | 0.86 | ALOX15 (0.40) | DRD2DRD3DRD1DRD4DRD5 | |
| SCHEMBL4228551 | 0.85 | CYP2A6 (0.43) | CYP2A6DRD2DRD3DRD1DRD4 | |
| Fumaric Acid SCHEMBL29403191 | 0.85 | HRH1 (0.42) | CYP2A6TSHRCYP1A2HRH1KDM4E | |
| SCHEMBL7424121 | 0.84 | — | — | |
| SCHEMBL17413659 | 0.81 | DRD2 (0.42) | DRD2DRD3TSHRGRIN1GRIN2B | |
| SCHEMBL8348677 | 0.81 | — | — | |
| SCHEMBL29538838 | 0.81 | HRH1 (0.45) | DRD2DRD3DRD1DRD4HTR2C | |
| SCHEMBL7255918 | 0.81 | HRH1 (0.45) | DRD2DRD3DRD1DRD4HTR2C | |
| SCHEMBL9948370 | 0.81 | ALOX15 (0.36) | DRD2DRD3DRD1DRD4DRD5 | |
| SCHEMBL21691013 | 0.80 | CYP2D6 (0.47) | GRIN1GRIN2BGRIN2DGRIN3BGRIN2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 44 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-12595234-B2 | Bioactive benzocycloheptene analogues from himachalenes and its applications | COUNCIL OF SCIENTIFIC & INDUSTRIAL RESEARCH (IN) | 2026-04-07 | — | — | US | disclosed |
| CN-114616229-B | Tricyclic compounds and pharmaceutical uses thereof | 镇斗生物科技股份公司 | 2024-09-03 | — | — | CN | disclosed |
| CN-116898799-B | Desloratadine oral preparation and preparation method thereof | 哈尔滨圣泰生物制药有限公司 | 2024-04-30 | — | — | CN | disclosed |
| CN-117447468-A | Bazedoxifene derivative and preparation method and application thereof | 中国药科大学 | 2024-01-26 | — | — | CN | disclosed |
| US-20230382860-A1 | Bioactive Benzocycloheptene Analogues From Himachalenes and its Applications | COUNCIL OF SCIENTIFIC & INDUSTRIAL RESEARCH (IN) | 2023-11-30 | — | — | US | disclosed |
| CN-116898799-A | Desloratadine oral preparation and preparation method thereof | 哈尔滨圣泰生物制药有限公司 | 2023-10-20 | — | — | CN | disclosed |
| CN-112220748-B | Desloratadine oral liquid preparation and preparation method thereof | 江苏阿尔法药业股份有限公司 | 2023-07-07 | — | — | CN | disclosed |
| CN-115616122-A | Method for separating and measuring related substances of loratadine starting material by liquid chromatography | 北京万全德众医药生物技术有限公司 | 2023-01-17 | — | — | CN | disclosed |
| US-20230002349-A1 | TRICYCLIC COMPOUND AND PHARMACEUTICAL USE THEREOF | JD BIOSCIENCE INC. (KR) | 2023-01-05 | — | — | US | disclosed |
| EP-4053116-A1 | TRICYCLIC COMPOUND AND PHARMACEUTICAL USE THEREOF | JD Bioscience Inc. (KR) | 2022-09-07 | — | — | EP | disclosed |
| US-6127366-A | ANTICARCINOGENIC OR ANTITUMOR AGENTS | MERCK & CO., INC. (US) | 2000-10-03 | — | — | US | disclosed |
| EP-1035852-A1 | INHIBITORS OF FARNESYL-PROTEIN TRANSFERASE | Merck & Co., Inc. (US) | 2000-09-20 | — | — | EP | disclosed |
| US-6054466-A | Inhibitors of farnesyl-protein transferase | MERCK & CO., INC. (US) | 2000-04-25 | — | — | US | disclosed |
| US-6015817-A | IMIDAZOLE-SUBSTITUTED THIENO(3,2-C)PYRIDINE DERIVATIVES; ANTICARCINOGENIC AGENTS, VIRICIDES; NERVOUS SYSTEM DISORDERS, VISION DEFECTS, KIDNEY DISEASES | MERCK & CO., INC. (US) | 2000-01-18 | — | — | US | disclosed |
| US-5977134-A | Inhibitors of farnesyl-protein transferase | MERCK & CO., INC. (US) | 1999-11-02 | — | — | US | disclosed |
| US-5972966-A | AND THE FARNESYLATION OF THE ONCOGENE PROTEIN RAS | MERCK & CO., INC. (US) | 1999-10-26 | — | — | US | disclosed |
| WO-1999027933-A1 | INHIBITORS OF FARNESYL-PROTEIN TRANSFERASE | MERCK & CO., INC. (US) | 1999-06-10 | — | — | WO | disclosed |
| WO-1999028314-A1 | INHIBITORS OF FARNESYL-PROTEIN TRANSFERASE | MERCK & CO., INC. (US) | 1999-06-10 | — | — | WO | disclosed |
| WO-1999028313-A1 | INHIBITORS OF FARNESYL-PROTEIN TRANSFERASE | MERCK & CO., INC. (US) | 1999-06-10 | — | — | WO | disclosed |
| EP-0042544-B1 | NOVEL ANTIHISTAMINES, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | SCHERING CORPORATION (US) | 1984-10-03 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-12595234-B2 | Bioactive benzocycloheptene analogues from himachalenes and its applications | CNR2, HK2, PIK3C2A | CYP2A6 154/4885DRD2 657/4885DRD3 1179/4885 |
| US-20230002349-A1 | TRICYCLIC COMPOUND AND PHARMACEUTICAL USE THEREOF | TPH1, SLC6A4, TPH2 | CYP2A6 225/4885DRD2 148/4885DRD3 220/4885 |
| US-20230382860-A1 | Bioactive Benzocycloheptene Analogues From Himachalenes and its Applications | HK2, GPR119, PIK3CD | CYP2A6 255/4885DRD2 684/4885DRD3 1647/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.