Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | SERPINE1 | P05121 | 2/20 | 0.35 |
| ▸ | AKR1C4 | P17516 | 1/20 | 0.35 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.35 |
| ▸ | AKR1C2 | P52895 | 1/20 | 0.35 |
| ▸ | AKR1C1 | Q04828 | 1/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.34 |
| ▸ | PTGDR2 | Q9Y5Y4 | 5/20 | 0.34 |
| ▸ | PTGDR | Q13258 | 3/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | TSHR | P16473 | 1/20 | 0.34 |
| ▸ | ACMSD | Q8TDX5 | 2/20 | 0.33 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.33 |
| ▸ | PTGER2 | P43116 | 1/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
| ▸ | TP53 | P04637 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7410883 | 1.00 | HSD17B10 (0.36) | HSD17B10KDM4ESERPINE1AKR1C4AKR1C3 | |
| SCHEMBL7413425 | 1.00 | HSD17B10 (0.36) | HSD17B10KDM4ESERPINE1AKR1C4AKR1C3 | |
| SCHEMBL7414700 | 0.84 | SLC6A3 (0.38) | HSD17B10KDM4EPTGDR2PTGDRALDH1A1 | |
| SCHEMBL7414698 | 0.84 | SLC6A3 (0.38) | HSD17B10KDM4EPTGDR2PTGDRALDH1A1 | |
| SCHEMBL7416434 | 0.81 | MAPT (0.34) | HSD17B10KDM4ESERPINE1AKR1C4AKR1C3 | |
| SCHEMBL9509212 | 0.77 | CYP2C9 (0.39) | KDM4EPTGDR2MAPTACMSDALDH1A1 | |
| SCHEMBL7418984 | 0.77 | CYP2C9 (0.39) | KDM4EPTGDR2MAPTACMSDALDH1A1 | |
| SCHEMBL7423284 | 0.76 | HSD11B1 (0.36) | MAPTTSHRACMSDGAA | |
| SCHEMBL9509199 | 0.75 | HTR3A (0.58) | CYP3A4TSHRALDH1A1 | |
| SCHEMBL7312354 | 0.73 | HSD17B10 (0.37) | HSD17B10KDM4ESERPINE1AKR1C4AKR1C3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0994871-A4 | NOVEL SUBSTITUTED NAPHTHOPYRANS | TRANSITIONS OPTICAL INC (US) | 2002-01-02 | — | — | EP | disclosed |
| EP-0994871-A1 | NOVEL SUBSTITUTED NAPHTHOPYRANS | TRANSITIONS OPTICAL, INC. (US) | 2000-04-26 | — | — | EP | disclosed |
| WO-1998055477-A1 | NOVEL SUBSTITUTED NAPHTHOPYRANS | TRANSITIONS OPTICAL, INC. (US) | 1998-12-10 | — | — | WO | disclosed |
| US-5288731-A | Antiemetics, antiserotonine agents | RHONE-POULENC RORER PHARMACEUTICALS INC. (US) | 1994-02-22 | — | — | US | disclosed |
| EP-0559656-A1 | PROCESS FOR PREPARING MULTICYCLIC OXY-CONTAINING RING COMPONENTS | RHONE-POULENC RORER INTERNATIONAL (HOLDINGS) INC. (US) | 1993-09-15 | — | — | EP | disclosed |
| WO-1992009592-A1 | PROCESS FOR PREPARING MULTICYCLIC OXY-CONTAINING RING COMPONENTS | RHONE-POULENC RORER INTERNATIONAL (HOLDINGS) INC. (US) | 1992-06-11 | — | — | WO | disclosed |
| WO-1992009284-A1 | 2,6-METHANO-2H-1-BENZOXOCINCARBOXAMIDES AS 5-HT3-ANTAGONISTS | RHONE-POULENC RORER INTERNATIONAL (HOLDINGS), INC. (US) | 1992-06-11 | — | — | WO | disclosed |