Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 2/20 | 0.41 |
| ▸ | AGTR1 | P30556 | 1/20 | 0.41 |
| ▸ | SMARCA2 | P51531 | 1/20 | 0.41 |
| ▸ | SMARCA4 | P51532 | 1/20 | 0.41 |
| ▸ | PBRM1 | Q86U86 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.39 |
| ▸ | MAOA | P21397 | 1/20 | 0.39 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.39 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.39 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.39 |
| ▸ | BCL2 | P10415 | 1/20 | 0.37 |
| ▸ | BCL2L1 | Q07817 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | ACHE | P22303 | 2/20 | 0.36 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.36 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1752856 | 0.81 | AGTR1 (0.38) | MAPTAGTR1SMARCA2SMARCA4PBRM1 | |
| SCHEMBL7438450 | 0.80 | MAPT (0.40) | MAPTAGTR1SMARCA2SMARCA4PBRM1 | |
| SCHEMBL1752842 | 0.76 | CASP1 (0.47) | SMARCA2SMARCA4PBRM1ALDH1A1BCL2 | |
| SCHEMBL14069624 | 0.75 | SMARCA2 (0.52) | MAPTAGTR1SMARCA2SMARCA4PBRM1 | |
| SCHEMBL1752808 | 0.73 | ACHE (0.51) | MAPTAGTR1SMARCA2SMARCA4PBRM1 | |
| SCHEMBL6380688 | 0.72 | PDE4A (0.43) | MAPTALDH1A1MEN1KMT2ACYP11B1 | |
| SCHEMBL1752913 | 0.70 | MEN1 (0.54) | MAPTAGTR1SMARCA2SMARCA4PBRM1 | |
| SCHEMBL1752930 | 0.69 | MEN1 (0.44) | MAPTMEN1KMT2ACYP11B1CYP11B2 | |
| SCHEMBL1752810 | 0.68 | SMARCA2 (0.56) | SMARCA2SMARCA4PBRM1MAOASMN1; SMN2 | |
| SCHEMBL1752934 | 0.68 | NPC1 (0.49) | KCNH2TDP1ACHE |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5278161-A | Racemic mixtures | HOFFMANN-LA ROCHE INC. (US) | 1994-01-11 | — | — | US | disclosed |
| EP-0464572-A2 | Aminoacid derivatives | F. HOFFMANN-LA ROCHE AG (CH) | 1992-01-08 | — | — | EP | disclosed |