Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ERAP2 | Q6P179 | 3/20 | 0.36 |
| ▸ | ERAP1 | Q9NZ08 | 1/20 | 0.36 |
| ▸ | CTSB | P07858 | 1/20 | 0.36 |
| ▸ | F2 | P00734 | 9/20 | 0.35 |
| ▸ | PLG | P00747 | 5/20 | 0.35 |
| ▸ | PLAT | P00750 | 5/20 | 0.35 |
| ▸ | PRSS1 | P07477 | 4/20 | 0.35 |
| ▸ | F10 | P00742 | 3/20 | 0.33 |
| ▸ | LNPEP | Q9UIQ6 | 1/20 | 0.32 |
| ▸ | GRIA1 | P42261 | 1/20 | 0.32 |
| ▸ | ENPEP | Q07075 | 1/20 | 0.32 |
| ▸ | IL1RN | P18510 | 1/20 | 0.31 |
| ▸ | MMP8 | P22894 | 1/20 | 0.31 |
| ▸ | CHRND | Q07001 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7423470 | 0.94 | F2 (0.41) | ERAP2ERAP1F2PLGPLAT | |
| SCHEMBL7416641 | 0.87 | CASP1 (0.34) | ERAP2ERAP1LNPEPIL1RNMMP8 | |
| SCHEMBL7286570 | 0.84 | CASP1 (0.40) | ERAP2ERAP1CTSBF2PLG | |
| SCHEMBL7417508 | 0.84 | CASP1 (0.35) | ERAP2ERAP1LNPEP | |
| SCHEMBL7304440 | 0.82 | F2 (0.38) | ERAP2ERAP1CTSBF2PLG | |
| SCHEMBL7414938 | 0.81 | KMT2A (0.35) | MMP8 | |
| SCHEMBL7283411 | 0.78 | CASP1 (0.47) | F2PLGPLATPRSS1F10 | |
| SCHEMBL7304203 | 0.75 | CTSC (0.45) | F2PLGPLATPRSS1F10 | |
| SCHEMBL7275336 | 0.72 | CASP1 (0.41) | CTSB | |
| SCHEMBL7284655 | 0.70 | CASP1 (0.44) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1993014777-A1 | PEPTIDYL DERIVATIVES AS INHIBITORS OF INTERLEUKIN-1β CONVERTING ENZYME | MERCK & CO., INC. (US) | 1993-08-05 | — | — | WO | disclosed |