Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CASP1 | P29466 | 7/20 | 0.34 |
| ▸ | CASP3 | P42574 | 4/20 | 0.34 |
| ▸ | CASP9 | P55211 | 3/20 | 0.34 |
| ▸ | CASP7 | P55210 | 2/20 | 0.34 |
| ▸ | FOLH1 | Q04609 | 2/20 | 0.33 |
| ▸ | MMP8 | P22894 | 1/20 | 0.33 |
| ▸ | ACE | P12821 | 1/20 | 0.33 |
| ▸ | LNPEP | Q9UIQ6 | 3/20 | 0.32 |
| ▸ | ERAP2 | Q6P179 | 3/20 | 0.32 |
| ▸ | ERAP1 | Q9NZ08 | 1/20 | 0.32 |
| ▸ | CASP4 | P49662 | 1/20 | 0.32 |
| ▸ | CASP5 | P51878 | 1/20 | 0.32 |
| ▸ | CASP6 | P55212 | 1/20 | 0.32 |
| ▸ | CASP8 | Q14790 | 1/20 | 0.32 |
| ▸ | CASP10 | Q92851 | 1/20 | 0.32 |
| ▸ | IL1RN | P18510 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7417508 | 0.97 | CASP1 (0.35) | CASP1CASP3CASP9CASP7FOLH1 | |
| SCHEMBL7424734 | 0.87 | ERAP2 (0.36) | MMP8LNPEPERAP2ERAP1IL1RN | |
| SCHEMBL7275336 | 0.86 | CASP1 (0.41) | CASP1CASP3CASP9CASP7CASP4 | |
| SCHEMBL7423470 | 0.86 | F2 (0.41) | LNPEPERAP2ERAP1 | |
| SCHEMBL7304749 | 0.84 | CTSC (0.41) | LNPEPERAP2ERAP1 | |
| SCHEMBL7283568 | 0.83 | CASP1 (0.43) | CASP1CASP3CASP9CASP7CASP4 | |
| SCHEMBL7414938 | 0.81 | KMT2A (0.35) | CASP1CASP3CASP7MMP8CASP8 | |
| SCHEMBL7303940 | 0.81 | CTSC (0.43) | CASP1LNPEPERAP2ERAP1 | |
| SCHEMBL7410461 | 0.72 | CASP3 (0.46) | CASP1CASP3CASP9CASP7 | |
| SCHEMBL7286570 | 0.72 | CASP1 (0.40) | CASP1CASP3ERAP2ERAP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1993014777-A1 | PEPTIDYL DERIVATIVES AS INHIBITORS OF INTERLEUKIN-1β CONVERTING ENZYME | MERCK & CO., INC. (US) | 1993-08-05 | — | — | WO | disclosed |