SCHEMBL7424874

SCHEMBL7424874

CC(CCc1ccccc1)NS(=O)(=O)CC(CCCN1C(=O)N(C)C(C)(C)C1=O)C(=O)O

nearest known ligand 0.41

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 5/20 0.41
CYP1A2 P05177 1/20 0.41
CYP2C9 P11712 1/20 0.41
CYP2C19 P33261 1/20 0.41
MMP2 P08253 2/20 0.40
MMP3 P08254 2/20 0.40
MMP9 P14780 2/20 0.40
MMP13 P45452 1/20 0.40
MMP1 P03956 1/20 0.37
MMP8 P22894 1/20 0.37
MEN1 O00255 2/20 0.37
HTT P42858 2/20 0.37
KMT2A Q03164 2/20 0.37
PLA2G7 Q13093 1/20 0.37
NR3C1 P04150 1/20 0.37
L3MBTL1 Q9Y468 1/20 0.37
SMN1; SMN2 Q16637 2/20 0.36
ACE P12821 1/20 0.36
POLB P06746 1/20 0.36
HPGD P15428 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6948795 0.86 KMT2A (0.40) ALDH1A1CYP2C9CYP2C19MMP2MMP3
SCHEMBL6948808 0.80 MMP3 (0.38) MMP2MMP3MMP9MMP13MMP1
SCHEMBL6952255 0.79 MMP2 (0.41) CYP1A2CYP2C19MMP2MMP3MMP9
SCHEMBL6947014 0.78 MMP2 (0.49) MMP2MMP3MMP9MMP13MMP1
SCHEMBL6948525 0.77 PLA2G7 (0.54) ALDH1A1MMP2MMP3MMP9MMP13
SCHEMBL6952582 0.76 MMP2 (0.38) MMP2MMP3MMP9MMP13MMP1
SCHEMBL6950782 0.74 MMP2 (0.39) ALDH1A1MMP2MMP3MMP9MMP13
SCHEMBL7424880 0.74 POLB (0.39) ALDH1A1CYP2C9CYP2C19MMP2MMP3
SCHEMBL6952757 0.73 MMP3 (0.48) MMP2MMP3MMP9MMP13MMP1
SCHEMBL6948796 0.72 PLA2G7 (0.39) ALDH1A1MMP2MMP3MMP9MMP13

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6187924-B1 INHIBITORS OF MATRIX METALLOPROTEINASES AND/OR TUMOR NECROSIS FACTOR-ALPHA-MEDIATED DISEASES DARWIN DISCOVERY, LTD. (GB) 2001-02-13 US claimed
EP-1030836-A1 HYDROXAMIC AND CARBOXYLIC ACID DERIVATIVES HAVING MMP AND TNF INHIBITORY ACTIVITY Darwin Discovery Limited (GB) 2000-08-30 EP disclosed
WO-1999024399-A1 HYDROXAMIC AND CARBOXYLIC ACID DERIVATIVES HAVING MMP AND TNF INHIBITORY ACTIVITY DARWIN DISCOVERY LIMITED (GB) 1999-05-20 WO disclosed