Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | MMP2 | P08253 | 3/20 | 0.40 |
| ▸ | MMP9 | P14780 | 3/20 | 0.40 |
| ▸ | MMP3 | P08254 | 2/20 | 0.40 |
| ▸ | MMP13 | P45452 | 1/20 | 0.40 |
| ▸ | MMP8 | P22894 | 2/20 | 0.40 |
| ▸ | MMP1 | P03956 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 3/20 | 0.39 |
| ▸ | PLA2G7 | Q13093 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | GRIK1 | P39086 | 1/20 | 0.36 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.35 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.35 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.35 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.35 |
| ▸ | TBXAS1 | P24557 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6947014 | 0.92 | MMP2 (0.49) | KMT2AMEN1MMP2MMP9MMP3 | |
| SCHEMBL6952255 | 0.87 | MMP2 (0.41) | MMP2MMP9MMP3MMP13MMP1 | |
| SCHEMBL7424874 | 0.86 | ALDH1A1 (0.41) | KMT2AMEN1MMP2MMP9MMP3 | |
| SCHEMBL6948525 | 0.85 | PLA2G7 (0.54) | KMT2AMEN1MMP2MMP9MMP3 | |
| SCHEMBL7424880 | 0.82 | POLB (0.39) | KMT2AMEN1MMP2MMP9MMP3 | |
| SCHEMBL6948808 | 0.81 | MMP3 (0.38) | KMT2AMEN1MMP2MMP9MMP3 | |
| SCHEMBL6948807 | 0.79 | MMP3 (0.49) | MMP2MMP9MMP3MMP13MMP8 | |
| SCHEMBL6948972 | 0.78 | PLA2G7 (0.52) | KMT2AMEN1MMP2MMP9MMP3 | |
| SCHEMBL6952001 | 0.78 | MMP13 (0.44) | KMT2AMMP2MMP9MMP3MMP13 | |
| SCHEMBL6954462 | 0.77 | MMP3 (0.56) | KMT2AMEN1MMP2MMP9MMP3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6187924-B1 | INHIBITORS OF MATRIX METALLOPROTEINASES AND/OR TUMOR NECROSIS FACTOR-ALPHA-MEDIATED DISEASES | DARWIN DISCOVERY, LTD. (GB) | 2001-02-13 | — | — | US | claimed |
| EP-1030836-B1 | HYDROXAMIC AND CARBOXYLIC ACID DERIVATIVES HAVING MMP AND TNF INHIBITORY ACTIVITY | DARWIN DISCOVERY LTD (GB) | 2003-01-29 | — | — | EP | disclosed |
| US-6187924-B1 | INHIBITORS OF MATRIX METALLOPROTEINASES AND/OR TUMOR NECROSIS FACTOR-ALPHA-MEDIATED DISEASES | DARWIN DISCOVERY, LTD. (GB) | 2001-02-13 | — | — | US | disclosed |
| EP-1030836-A1 | HYDROXAMIC AND CARBOXYLIC ACID DERIVATIVES HAVING MMP AND TNF INHIBITORY ACTIVITY | Darwin Discovery Limited (GB) | 2000-08-30 | — | — | EP | disclosed |
| WO-1999024399-A1 | HYDROXAMIC AND CARBOXYLIC ACID DERIVATIVES HAVING MMP AND TNF INHIBITORY ACTIVITY | DARWIN DISCOVERY LIMITED (GB) | 1999-05-20 | — | — | WO | disclosed |