SCHEMBL7424901

SCHEMBL7424901

O=C(O)COc1c(Cl)c(Cl)c(Cl)c(Cl)c1Cl

nearest known ligand 0.57

Predicted protein targets (top 15)

geneUniProtsupporting neighboursconfidence
KMT2A Q03164 1/20 0.57
CD69 Q07108 4/20 0.45
TSHR P16473 1/20 0.44
SMN1; SMN2 Q16637 1/20 0.44
KDM4E B2RXH2 2/20 0.43
ALOX15 P16050 1/20 0.43
TDP1 Q9NUW8 1/20 0.42
PTPN1 P18031 1/20 0.41
HIF1A Q16665 1/20 0.41
HPGD P15428 1/20 0.40
MCL1 Q07820 1/20 0.40
PKM P14618 1/20 0.39
HTT P42858 1/20 0.39
ELANE P08246 1/20 0.39
MAPT P10636 1/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL1525621 0.98 KMT2A (0.55) KMT2ACD69TSHRSMN1; SMN2KDM4E
SCHEMBL11568841 0.82 KMT2A (0.60) KMT2ACD69TSHRKDM4EALOX15
SCHEMBL1525620 0.76 KMT2A (0.35) KMT2AHIF1A
SCHEMBL11573013 0.76 MCL1 (0.52) KMT2ATSHRMCL1
SCHEMBL30435946 0.76 KMT2A (0.69) KMT2ACD69TSHRKDM4EALOX15
SCHEMBL7431498 0.75 LMNA (0.52) KMT2ATSHRSMN1; SMN2KDM4EHIF1A
SCHEMBL3729436 0.73 KMT2A (1.00) KMT2ACD69KDM4EALOX15TDP1
SCHEMBL481443 0.73 KMT2A (0.66) KMT2ATSHRKDM4ETDP1HIF1A
SCHEMBL9169346 0.73 OGG1 (0.54) KDM4EHPGDMAPT
SCHEMBL13868005 0.72 PTPN1 (0.56) KMT2ACD69KDM4EPTPN1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 17 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1155010-A1 ACETAMIDO ACETONITRILE DERIVATIVES AS INHIBITORS OF CATHEPSIN L AND/OR CATHEPSIN S AstraZeneca AB (SE) 2001-11-21 EP disclosed
WO-2000049007-A1 ACETAMIDO ACETONITRILE DERIVATIVES AS INHIBITORS OF CATHEPSIN L AND/OR CATHEPSIN S ASTRAZENECA AB (SE) 2000-08-24 WO disclosed
US-4347194-A Polyhydroxyl polyether compounds containing phosphorus THE DOW CHEMICAL CO. (US) 1982-08-31 US disclosed
US-4298709-A FIREPROOFING, AGING RESISTANCE THE DOW CHEMICAL COMPANY (US) 1981-11-03 US disclosed
US-4230813-A CROSSLINKED STYRENE TERPOLYMER ADDITIVE HOOKER CHEMICALS & PLASTICS CORP. (US) 1980-10-28 US disclosed
US-4195014-A Unsatured polyester resins having improved fire retardance HOOKER CHEMICALS & PLASTICS CORP. (US) 1980-03-25 US disclosed
US-4179536-A ANITFUNGAL TRIBUTYLTIN COMPOUNDS KASAMATSU HIROSHI 1979-12-18 US disclosed
US-4152368-A CONTAINING IRON, ANTIMONY, COPPER, OR THEIR COMPOUNDS HOOKER CHEMICALS & PLASTICS CORP. (US) 1979-05-01 US disclosed
US-4125702-A Additive for low profile polymerizable unsaturated polyester molding composition HOOKER CHEMICALS & PLASTICS CORP. (US) 1978-11-14 US disclosed
US-4100229-A Low profile additives in polyester systems HOOKER CHEMICALS & PLASTICS CORP. (US) 1978-07-11 US disclosed
US-4049749-A CROSSLINKED ACRYLATE POLYMER HOOKER CHEMICALS & PLASTICS CORPORATION (US) 1977-09-20 US disclosed
US-4043988-A Low profile polyester molding composition HOOKER CHEMICALS & PLASTICS CORPORATION (US) 1977-08-23 US disclosed
US-4038342-A STYRENE-MALEIC ANHYDRIDE COPOLYMER REACTED WITH HYDROXYL TERMINATED SATURATED POLYESTER HOOKER CHEMICALS & PLASTICS CORPORATION (US) 1977-07-26 US disclosed
US-4038341-A REACTION PRODUCT OF MALEIC ANHYDRIDE-STYRENE COPOLYMER AND HYDROXYL-TERMINATED POLYBUTADIENE HOOKER CHEMICALS & PLASTICS CORPORATION (US) 1977-07-26 US disclosed
US-4013815-A FIRE RETARDANT UNSATURATED POLYESTERS HOOKER CHEMICALS & PLASTICS CORPORATION (US) 1977-03-22 US disclosed
US-3992480-A USED IN LAMINATED ARTICLES HOOKER CHEMICALS & PLASTICS CORPORATION (US) 1976-11-16 US disclosed
US-3983185-A Halogen containing polyester resins having improved smoke-resistance HOOKER CHEMICALS & PLASTICS CORPORATION (US) 1976-09-28 US disclosed