Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRN | P28799 | 3/20 | 0.44 |
| ▸ | SORT1 | Q99523 | 3/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | BCL2L1 | Q07817 | 1/20 | 0.39 |
| ▸ | HTR2A | P28223 | 3/20 | 0.37 |
| ▸ | SLC6A4 | P31645 | 3/20 | 0.37 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.37 |
| ▸ | TSPO | P30536 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | PTGFR | P43088 | 3/20 | 0.36 |
| ▸ | LTA4H | P09960 | 1/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7424962 | 0.82 | GRN (0.47) | GRNSORT1MAPK1ALDH1A1LMNA | |
| SCHEMBL7428201 | 0.81 | GRN (0.46) | GRNSORT1MAPK1ALDH1A1LMNA | |
| SCHEMBL7427491 | 0.80 | ENPP2 (0.45) | MAPK1 | |
| SCHEMBL8250493 | 0.76 | ACE2 (0.48) | GRNSORT1MAPK1BCL2L1LTA4H | |
| SCHEMBL5869280 | 0.76 | ACE2 (0.48) | GRNSORT1MAPK1BCL2L1LTA4H | |
| SCHEMBL7425294 | 0.74 | MAPT (0.41) | MAPK1 | |
| SCHEMBL7422599 | 0.73 | GRN (0.47) | GRNSORT1MAPK1ALDH1A1LMNA | |
| SCHEMBL7419482 | 0.73 | GRN (0.49) | GRNSORT1MAPK1ALDH1A1LMNA | |
| SCHEMBL7423140 | 0.72 | CTSS (0.48) | BCL2L1ALDH1A1 | |
| SCHEMBL7424624 | 0.72 | GRN (0.44) | GRNSORT1MAPK1ALDH1A1POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2002039997-A2 | ACE-2 MODULATING COMPOUNDS AND USE THEREOF | MILLENNIUM PHARMACEUTICALS, INC. (US) | 2002-05-23 | — | — | WO | claimed |
| WO-2002039997-A2 | ACE-2 MODULATING COMPOUNDS AND USE THEREOF | MILLENNIUM PHARMACEUTICALS, INC. (US) | 2002-05-23 | — | — | WO | disclosed |