Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRN | P28799 | 4/20 | 0.49 |
| ▸ | SORT1 | Q99523 | 4/20 | 0.49 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.43 |
| ▸ | PSEN2 | P49810 | 1/20 | 0.43 |
| ▸ | APH1B | Q8WW43 | 1/20 | 0.43 |
| ▸ | NCSTN | Q92542 | 1/20 | 0.43 |
| ▸ | APH1A | Q96BI3 | 1/20 | 0.43 |
| ▸ | PSENEN | Q9NZ42 | 1/20 | 0.43 |
| ▸ | CTSS | P25774 | 1/20 | 0.43 |
| ▸ | CTSK | P43235 | 1/20 | 0.43 |
| ▸ | APP | P05067 | 1/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | MMP1 | P03956 | 1/20 | 0.39 |
| ▸ | MMP2 | P08253 | 1/20 | 0.39 |
| ▸ | MMP3 | P08254 | 1/20 | 0.39 |
| ▸ | MMP7 | P09237 | 1/20 | 0.39 |
| ▸ | MMP9 | P14780 | 1/20 | 0.39 |
| ▸ | MMP13 | P45452 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7422599 | 0.88 | GRN (0.47) | GRNSORT1PSEN1PSEN2APH1B | |
| SCHEMBL7419023 | 0.86 | GRN (0.47) | GRNSORT1MAPK1ALDH1A1LMNA | |
| SCHEMBL7428201 | 0.85 | GRN (0.46) | GRNSORT1CTSSCTSKMAPK1 | |
| SCHEMBL7424801 | 0.85 | CTSS (0.46) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL7425607 | 0.84 | CTSL (0.48) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL7426644 | 0.83 | GRN (0.50) | GRNSORT1MAPK1ALDH1A1POLB | |
| SCHEMBL7427413 | 0.82 | CTSS (0.48) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL7420389 | 0.82 | CTSS (0.48) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL7424624 | 0.82 | GRN (0.44) | GRNSORT1CTSSCTSKMAPK1 | |
| SCHEMBL7424962 | 0.81 | GRN (0.47) | GRNSORT1APPMAPK1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2002039997-A2 | ACE-2 MODULATING COMPOUNDS AND USE THEREOF | MILLENNIUM PHARMACEUTICALS, INC. (US) | 2002-05-23 | — | — | WO | claimed |
| WO-2002039997-A2 | ACE-2 MODULATING COMPOUNDS AND USE THEREOF | MILLENNIUM PHARMACEUTICALS, INC. (US) | 2002-05-23 | — | — | WO | disclosed |