Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.51 |
| ▸ | LMNA | P02545 | 2/20 | 0.48 |
| ▸ | NR1H3 | Q13133 | 2/20 | 0.47 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.47 |
| ▸ | ABCB1 | P08183 | 2/20 | 0.44 |
| ▸ | SMPD1 | P17405 | 1/20 | 0.44 |
| ▸ | DRD2 | P14416 | 1/20 | 0.43 |
| ▸ | PDE4A | P27815 | 1/20 | 0.42 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.42 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.42 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11743353 | 0.82 | ALDH1A1 (0.69) | ALDH1A1LMNANR1H3NR1H2 | |
| SCHEMBL7425987 | 0.81 | SMPD1 (0.47) | ABCB1SMPD1 | |
| SCHEMBL8707317 | 0.80 | NR1H3 (0.51) | ALDH1A1LMNANR1H3NR1H2PDE4A | |
| SCHEMBL9053567 | 0.77 | ALDH1A1 (0.67) | ALDH1A1LMNANR1H3NR1H2 | |
| SCHEMBL4637258 | 0.77 | PDE4A (0.55) | PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL8712860 | 0.75 | QPCT (0.43) | NR1H3NR1H2PDE4APDE4BPDE4C | |
| SCHEMBL8777049 | 0.74 | LMNA (0.72) | ALDH1A1LMNANR1H3NR1H2 | |
| SCHEMBL8711619 | 0.73 | CMA1 (0.42) | ALDH1A1PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL8708949 | 0.73 | HTR2C (0.46) | ALDH1A1 | |
| SCHEMBL8711349 | 0.73 | HTR2C (0.46) | ALDH1A1NR1H3NR1H2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0874819-A1 | IMIDES AS PDE III, PDE IV AND TNF INHIBITORS | CELGENE CORPORATION (US) | 1998-11-04 | — | — | EP | disclosed |
| WO-1997023457-A1 | IMIDES AS PDE III, PDE IV AND TNF INHIBITORS | CELGENE CORPORATION (US) | 1997-07-03 | — | — | WO | disclosed |