Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4A | P27815 | 14/20 | 0.55 |
| ▸ | PDE4B | Q07343 | 14/20 | 0.55 |
| ▸ | PDE4C | Q08493 | 14/20 | 0.55 |
| ▸ | PDE4D | Q08499 | 14/20 | 0.55 |
| ▸ | TNF | P01375 | 7/20 | 0.53 |
| ▸ | UTS2R | Q9UKP6 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4637260 | 0.83 | FFAR1 (0.39) | PDE4APDE4BPDE4CPDE4DTNF | |
| SCHEMBL4637197 | 0.81 | PDE4A (0.79) | PDE4APDE4BPDE4CPDE4DTNF | |
| SCHEMBL7400893 | 0.81 | TNF (0.76) | PDE4APDE4BPDE4CPDE4DTNF | |
| SCHEMBL8707317 | 0.80 | NR1H3 (0.51) | PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL4637327 | 0.79 | FFAR1 (0.43) | PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL7424982 | 0.77 | ALDH1A1 (0.51) | PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL14269350 | 0.75 | TNF (0.64) | PDE4APDE4BPDE4CPDE4DTNF | |
| SCHEMBL8712860 | 0.75 | QPCT (0.43) | PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL9977546 | 0.73 | PDE4A (0.80) | PDE4APDE4BPDE4CPDE4DTNF | |
| SCHEMBL4637613 | 0.72 | PDE4A (0.80) | PDE4APDE4BPDE4CPDE4DTNF |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1468991-B1 | Imides as PDE III, PDE IV and TNF inhibitors | CELGENE CORP (US) | 2008-02-20 | — | — | EP | claimed |
| EP-1468991-B1 | Imides as PDE III, PDE IV and TNF inhibitors | CELGENE CORP (US) | 2008-02-20 | — | — | EP | disclosed |
| EP-1468991-A1 | Imides as PDE III, PDE IV and TNF inhibitors | CELGENE CORPORATION (US) | 2004-10-20 | — | — | EP | disclosed |
| EP-0874819-B1 | IMIDES AS PDE III, PDE IV AND TNF INHIBITORS | CELGENE CORP (US) | 2004-05-26 | — | — | EP | disclosed |
| US-5728844-A | INHIBITORS OF TUMOR NECROSIS AND PHOSPHODIESTERASE | CELGENE CORPORATION (US) | 1998-03-17 | — | — | US | disclosed |