Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PPARA | Q07869 | 6/20 | 0.56 |
| ▸ | PPARG | P37231 | 5/20 | 0.56 |
| ▸ | CTSK | P43235 | 6/20 | 0.53 |
| ▸ | CTSS | P25774 | 6/20 | 0.53 |
| ▸ | PPARD | Q03181 | 2/20 | 0.52 |
| ▸ | MMP13 | P45452 | 2/20 | 0.51 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.51 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.51 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.51 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.51 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.51 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.51 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.51 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.51 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.51 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.51 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.51 |
| ▸ | NCOR2 | Q9Y618 | 1/20 | 0.51 |
| ▸ | CTSB | P07858 | 3/20 | 0.49 |
| ▸ | CTSL | P07711 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8146699 | 0.90 | PPARA (0.69) | PPARAPPARGCTSKCTSSPPARD | |
| SCHEMBL4365866 | 0.82 | CTSS (0.74) | PPARAPPARGCTSKCTSSMMP13 | |
| SCHEMBL18661099 | 0.82 | CTSS (0.74) | PPARAPPARGCTSKCTSSMMP13 | |
| SCHEMBL4374188 | 0.82 | CTSS (0.74) | PPARAPPARGCTSKCTSSMMP13 | |
| SCHEMBL7428634 | 0.81 | CYP1A2 (0.49) | PPARAPPARGCTSKCTSSPPARD | |
| SCHEMBL30788955 | 0.80 | CTSK (0.53) | PPARAPPARGCTSKCTSSPPARD | |
| SCHEMBL7437488 | 0.80 | PSEN1 (0.49) | — | |
| SCHEMBL8951298 | 0.80 | CTSS (0.73) | CTSKCTSSMMP13HDAC3HDAC4 | |
| SCHEMBL5921660 | 0.78 | PPARG (0.56) | PPARAPPARGCTSKCTSSPPARD | |
| SCHEMBL1374859 | 0.76 | CTSK (0.63) | PPARAPPARGCTSKCTSSPPARD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6018020-A | VIRICIDES WHICH ARE PROTEASE INHIBITORS AGAINST HEPATITIS C AND HEPATITIS G | HOFFMAN-LA ROCHE INC. (US) | 2000-01-25 | — | — | US | disclosed |
| EP-0941233-A2 | ANTIVIRAL PEPTIDE DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 1999-09-15 | — | — | EP | disclosed |
| US-5866684-A | Peptidyl inhibitors of viral proteases | HOFFMANN-LA ROCHE INC. (US) | 1999-02-02 | — | — | US | disclosed |
| WO-1998022496-A2 | ANTIVIRAL PEPTIDE DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 1998-05-28 | — | — | WO | disclosed |