Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PSEN1 | P49768 | 2/20 | 0.49 |
| ▸ | PSEN2 | P49810 | 2/20 | 0.49 |
| ▸ | APH1B | Q8WW43 | 2/20 | 0.49 |
| ▸ | NCSTN | Q92542 | 2/20 | 0.49 |
| ▸ | APH1A | Q96BI3 | 2/20 | 0.49 |
| ▸ | PSENEN | Q9NZ42 | 2/20 | 0.49 |
| ▸ | BACE1 | P56817 | 14/20 | 0.48 |
| ▸ | REN | P00797 | 4/20 | 0.48 |
| ▸ | BACE2 | Q9Y5Z0 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7437679 | 0.88 | PPARG (0.58) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL9697661 | 0.83 | CTSS (0.54) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL8146699 | 0.80 | PPARA (0.69) | — | |
| SCHEMBL7433466 | 0.80 | BACE1 (0.48) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL7425266 | 0.80 | PPARA (0.56) | — | |
| SCHEMBL7437492 | 0.79 | REN (0.49) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL10767995 | 0.78 | REN (0.51) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL7441770 | 0.77 | PSEN1 (0.49) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL15316224 | 0.76 | CTSK (0.53) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL10722632 | 0.75 | REN (0.59) | BACE1REN |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4826815-A | HYPOTENSIVE | ABBOTT LABORATORIES (US) | 1989-05-02 | — | — | US | disclosed |
| US-4645759-A | HYPOTENSIVE AGENTS | ABBOTT LABORATORIES (US) | 1987-02-24 | — | — | US | disclosed |
| EP-0172347-A2 | Renin inhibiting compounds | ABBOTT LABORATORIES (US) | 1986-02-26 | — | — | EP | disclosed |