Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KEAP1 | Q14145 | 1/20 | 0.43 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.43 |
| ▸ | FFAR1 | O14842 | 5/20 | 0.40 |
| ▸ | FFAR4 | Q5NUL3 | 4/20 | 0.40 |
| ▸ | MAOB | P27338 | 1/20 | 0.40 |
| ▸ | CPB1 | P15086 | 1/20 | 0.39 |
| ▸ | SLC22A12 | Q96S37 | 2/20 | 0.38 |
| ▸ | C5AR1 | P21730 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.36 |
| ▸ | PTGER4 | P35408 | 1/20 | 0.36 |
| ▸ | CMA1 | P23946 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7428935 | 0.91 | KEAP1 (0.41) | KEAP1NFE2L2FFAR4CPB1SLC22A12 | |
| SCHEMBL7425284 | 0.86 | KEAP1 (0.41) | KEAP1NFE2L2FFAR4CPB1C5AR1 | |
| SCHEMBL7424617 | 0.81 | MAOB (0.42) | FFAR1FFAR4MAOB | |
| SCHEMBL8248789 | 0.79 | KEAP1 (0.43) | KEAP1NFE2L2FFAR1FFAR4MAOB | |
| SCHEMBL5869605 | 0.79 | KEAP1 (0.43) | KEAP1NFE2L2FFAR1FFAR4MAOB | |
| SCHEMBL7423336 | 0.76 | PARP10 (0.46) | FFAR1FFAR4 | |
| SCHEMBL7428192 | 0.74 | CARM1 (0.46) | FFAR1 | |
| SCHEMBL7424454 | 0.74 | NR4A2 (0.49) | FFAR1MAOB | |
| SCHEMBL7425296 | 0.74 | KEAP1 (0.42) | KEAP1NFE2L2FFAR1FFAR4CPB1 | |
| SCHEMBL7426589 | 0.74 | MAOB (0.51) | FFAR1MAOB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2002039997-A2 | ACE-2 MODULATING COMPOUNDS AND USE THEREOF | MILLENNIUM PHARMACEUTICALS, INC. (US) | 2002-05-23 | — | — | WO | claimed |