Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KEAP1 | Q14145 | 1/20 | 0.42 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.42 |
| ▸ | FFAR4 | Q5NUL3 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 2/20 | 0.38 |
| ▸ | CPB1 | P15086 | 1/20 | 0.37 |
| ▸ | CYP2A6 | P11509 | 2/20 | 0.35 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.35 |
| ▸ | CA2 | P00918 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.35 |
| ▸ | NR4A2 | P43354 | 1/20 | 0.34 |
| ▸ | FFAR2 | O15552 | 1/20 | 0.34 |
| ▸ | EGFR | P00533 | 1/20 | 0.34 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.34 |
| ▸ | EPHA2 | P29317 | 1/20 | 0.34 |
| ▸ | KDR | P35968 | 1/20 | 0.34 |
| ▸ | EPHB4 | P54760 | 1/20 | 0.34 |
| ▸ | KLKB1 | P03952 | 1/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7428942 | 0.91 | KEAP1 (0.40) | KEAP1NFE2L2FFAR4MAPTCPB1 | |
| SCHEMBL7425294 | 0.84 | MAPT (0.41) | KEAP1NFE2L2FFAR4MAPTCPB1 | |
| SCHEMBL8248789 | 0.82 | KEAP1 (0.43) | KEAP1NFE2L2FFAR4MAPTCPB1 | |
| SCHEMBL5869605 | 0.82 | KEAP1 (0.43) | KEAP1NFE2L2FFAR4MAPTCPB1 | |
| SCHEMBL7424624 | 0.79 | GRN (0.44) | MAPTALDH1A1FFAR1MAPK1 | |
| SCHEMBL5869794 | 0.77 | MME (0.42) | KEAP1NFE2L2MAPTMAPK1 | |
| SCHEMBL5869800 | 0.77 | MME (0.42) | KEAP1NFE2L2MAPTMAPK1 | |
| SCHEMBL5870047 | 0.77 | MME (0.42) | KEAP1NFE2L2MAPTMAPK1 | |
| SCHEMBL7425531 | 0.77 | MME (0.42) | KEAP1NFE2L2MAPTMAPK1 | |
| SCHEMBL7425285 | 0.74 | KEAP1 (0.43) | KEAP1NFE2L2FFAR4MAPTCPB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2002039997-A2 | ACE-2 MODULATING COMPOUNDS AND USE THEREOF | MILLENNIUM PHARMACEUTICALS, INC. (US) | 2002-05-23 | — | — | WO | claimed |