Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.41 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.41 |
| ▸ | FFAR4 | Q5NUL3 | 1/20 | 0.38 |
| ▸ | EGFR | P00533 | 1/20 | 0.36 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.36 |
| ▸ | EPHA2 | P29317 | 1/20 | 0.36 |
| ▸ | KDR | P35968 | 1/20 | 0.36 |
| ▸ | EPHB4 | P54760 | 1/20 | 0.36 |
| ▸ | PKM | P14618 | 1/20 | 0.36 |
| ▸ | CPB1 | P15086 | 1/20 | 0.36 |
| ▸ | PDCD1 | Q15116 | 1/20 | 0.36 |
| ▸ | CD274 | Q9NZQ7 | 1/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.35 |
| ▸ | CMA1 | P23946 | 1/20 | 0.35 |
| ▸ | NTSR1 | P30989 | 2/20 | 0.34 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.34 |
| ▸ | CA2 | P00918 | 1/20 | 0.34 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7425296 | 0.84 | KEAP1 (0.42) | MAPTKEAP1NFE2L2FFAR4EGFR | |
| SCHEMBL7428942 | 0.84 | KEAP1 (0.40) | MAPTKEAP1NFE2L2FFAR4EGFR | |
| SCHEMBL8249919 | 0.82 | MAPT (0.43) | MAPTKEAP1NFE2L2FFAR4EGFR | |
| SCHEMBL5870095 | 0.82 | MAPT (0.43) | MAPTKEAP1NFE2L2FFAR4EGFR | |
| SCHEMBL7427491 | 0.80 | ENPP2 (0.45) | FFAR4PDCD1CD274MAPK1 | |
| SCHEMBL8258434 | 0.76 | MAPT (0.39) | MAPTKEAP1NFE2L2PKMPDCD1 | |
| SCHEMBL7422452 | 0.74 | GRN (0.44) | MAPK1 | |
| SCHEMBL5869605 | 0.74 | KEAP1 (0.43) | MAPTKEAP1NFE2L2FFAR4CPB1 | |
| SCHEMBL8248789 | 0.74 | KEAP1 (0.43) | MAPTKEAP1NFE2L2FFAR4CPB1 | |
| SCHEMBL5869800 | 0.73 | MME (0.42) | MAPTKEAP1NFE2L2PKMCD274 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2002039997-A2 | ACE-2 MODULATING COMPOUNDS AND USE THEREOF | MILLENNIUM PHARMACEUTICALS, INC. (US) | 2002-05-23 | — | — | WO | claimed |
| WO-2002039997-A2 | ACE-2 MODULATING COMPOUNDS AND USE THEREOF | MILLENNIUM PHARMACEUTICALS, INC. (US) | 2002-05-23 | — | — | WO | disclosed |