Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ROCK1 | Q13464 | 14/20 | 0.41 |
| ▸ | ROCK2 | O75116 | 13/20 | 0.41 |
| ▸ | PARP1 | P09874 | 1/20 | 0.40 |
| ▸ | PRKACA | P17612 | 1/20 | 0.38 |
| ▸ | FNTA | P49354 | 1/20 | 0.38 |
| ▸ | FNTB | P49356 | 1/20 | 0.38 |
| ▸ | PGGT1B | P53609 | 1/20 | 0.38 |
| ▸ | CAPN1 | P07384 | 2/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | STAT3 | P40763 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7426239 | 0.93 | MEN1 (0.43) | CAPN1MEN1STAT3KMT2A | |
| SCHEMBL7424812 | 0.86 | SMN1; SMN2 (0.34) | FNTAFNTBPGGT1BCAPN1MEN1 | |
| SCHEMBL7426448 | 0.85 | GRN (0.44) | CAPN1MEN1KMT2A | |
| SCHEMBL7425252 | 0.81 | CTSK (0.54) | FNTAFNTBPGGT1BMEN1KMT2A | |
| SCHEMBL4714130 | 0.80 | MEN1 (0.46) | MEN1STAT3KMT2A | |
| SCHEMBL7419514 | 0.79 | FNTA (0.38) | FNTAFNTBPGGT1B | |
| SCHEMBL7427413 | 0.79 | CTSS (0.48) | ROCK1ROCK2PRKACAFNTAFNTB | |
| SCHEMBL7420389 | 0.79 | CTSS (0.48) | ROCK1ROCK2PRKACAFNTAFNTB | |
| SCHEMBL4714337 | 0.76 | CTSK (0.58) | — | |
| SCHEMBL5869695 | 0.75 | ROCK1 (0.42) | ROCK1ROCK2PARP1PRKACAFNTA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2002039997-A2 | ACE-2 MODULATING COMPOUNDS AND USE THEREOF | MILLENNIUM PHARMACEUTICALS, INC. (US) | 2002-05-23 | — | — | WO | claimed |
| WO-2002039997-A2 | ACE-2 MODULATING COMPOUNDS AND USE THEREOF | MILLENNIUM PHARMACEUTICALS, INC. (US) | 2002-05-23 | — | — | WO | disclosed |