Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTSK | P43235 | 3/20 | 0.54 |
| ▸ | LDHA | P00338 | 1/20 | 0.42 |
| ▸ | LDHB | P07195 | 1/20 | 0.42 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | FNTA | P49354 | 1/20 | 0.39 |
| ▸ | FNTB | P49356 | 1/20 | 0.39 |
| ▸ | PGGT1B | P53609 | 1/20 | 0.39 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.38 |
| ▸ | CDK5R1 | Q15078 | 1/20 | 0.38 |
| ▸ | GPR142 | Q7Z601 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.38 |
| ▸ | MAPT | P10636 | 2/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.37 |
| ▸ | AR | P10275 | 1/20 | 0.37 |
| ▸ | CTSL | P07711 | 3/20 | 0.37 |
| ▸ | CTSB | P07858 | 3/20 | 0.37 |
| ▸ | CTSS | P25774 | 3/20 | 0.37 |
| ▸ | AAK1 | Q2M2I8 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1655302 | 0.93 | CTSK (0.62) | CTSKLDHALDHBKDM4ESMN1; SMN2 | |
| SCHEMBL7426736 | 0.85 | CTSK (0.48) | CTSKLDHALDHBFNTAFNTB | |
| SCHEMBL7422285 | 0.84 | CTSK (0.47) | CTSKLDHALDHBKDM4ESMN1; SMN2 | |
| SCHEMBL7417883 | 0.84 | CTSK (0.55) | CTSKLDHALDHBCDK5CDK5R1 | |
| SCHEMBL7421947 | 0.83 | CTSK (0.56) | CTSKLDHALDHBKDM4ESMN1; SMN2 | |
| SCHEMBL7420772 | 0.81 | ALDH1A1 (0.51) | CTSKKDM4ESMN1; SMN2MAPTHTT | |
| SCHEMBL7425602 | 0.81 | ROCK1 (0.41) | FNTAFNTBPGGT1BKMT2AMEN1 | |
| SCHEMBL7382345 | 0.81 | CTSK (0.41) | CTSKSMN1; SMN2MAPTHTTKMT2A | |
| SCHEMBL4713366 | 0.80 | CTSK (0.70) | CTSKLDHALDHBHPGDKDM4E | |
| SCHEMBL7427413 | 0.80 | CTSS (0.48) | CTSKFNTAFNTBPGGT1BCDK5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2002039997-A2 | ACE-2 MODULATING COMPOUNDS AND USE THEREOF | MILLENNIUM PHARMACEUTICALS, INC. (US) | 2002-05-23 | — | — | WO | claimed |
| WO-2002039997-A2 | ACE-2 MODULATING COMPOUNDS AND USE THEREOF | MILLENNIUM PHARMACEUTICALS, INC. (US) | 2002-05-23 | — | — | WO | disclosed |