Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 9/20 | 0.61 |
| ▸ | MAPT | P10636 | 6/20 | 0.61 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.61 |
| ▸ | PYGL | P06737 | 1/20 | 0.57 |
| ▸ | TAS1R3 | Q7RTX0 | 1/20 | 0.55 |
| ▸ | TAS1R1 | Q7RTX1 | 1/20 | 0.55 |
| ▸ | CTSL | P07711 | 1/20 | 0.53 |
| ▸ | CTSS | P25774 | 1/20 | 0.53 |
| ▸ | NPC1 | O15118 | 3/20 | 0.51 |
| ▸ | RAB9A | P51151 | 3/20 | 0.51 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.50 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.50 |
| ▸ | LMNA | P02545 | 1/20 | 0.50 |
| ▸ | HPGD | P15428 | 1/20 | 0.50 |
| ▸ | HTT | P42858 | 1/20 | 0.50 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.50 |
| ▸ | BCAT1 | P54687 | 1/20 | 0.48 |
| ▸ | XDH | P47989 | 1/20 | 0.47 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.47 |
| ▸ | MEN1 | O00255 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5869272 | 0.84 | KDM4E (0.58) | KDM4EMAPTALDH1A1PYGLTAS1R3 | |
| SCHEMBL5869262 | 0.84 | KDM4E (0.58) | KDM4EMAPTALDH1A1PYGLTAS1R3 | |
| SCHEMBL5869279 | 0.84 | KDM4E (0.58) | KDM4EMAPTALDH1A1PYGLTAS1R3 | |
| SCHEMBL24019692 | 0.80 | KDM4E (0.77) | KDM4EMAPTALDH1A1PYGLNPC1 | |
| SCHEMBL5822796 | 0.78 | TAS1R3 (0.58) | KDM4EALDH1A1PYGLTAS1R3TAS1R1 | |
| SCHEMBL7426574 | 0.76 | CTSL (0.59) | ALDH1A1TAS1R3TAS1R1CTSLCTSS | |
| SCHEMBL20853657 | 0.76 | TAS1R3 (0.78) | PYGLTAS1R3TAS1R1CTSLCTSS | |
| SCHEMBL25517392 | 0.76 | TAS1R3 (0.78) | PYGLTAS1R3TAS1R1CTSLCTSS | |
| SCHEMBL25197064 | 0.76 | TAS1R3 (0.78) | PYGLTAS1R3TAS1R1CTSLCTSS | |
| SCHEMBL17149703 | 0.75 | KDM4E (0.66) | KDM4EMAPTALDH1A1PYGLNPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2002039997-A2 | ACE-2 MODULATING COMPOUNDS AND USE THEREOF | MILLENNIUM PHARMACEUTICALS, INC. (US) | 2002-05-23 | — | — | WO | disclosed |