Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP1 | P03956 | 18/20 | 0.54 |
| ▸ | REN | P00797 | 1/20 | 0.45 |
| ▸ | MMP3 | P08254 | 8/20 | 0.44 |
| ▸ | MMP8 | P22894 | 7/20 | 0.44 |
| ▸ | MMP2 | P08253 | 7/20 | 0.44 |
| ▸ | MMP9 | P14780 | 5/20 | 0.44 |
| ▸ | MMP7 | P09237 | 4/20 | 0.44 |
| ▸ | FCER2 | P06734 | 1/20 | 0.44 |
| ▸ | ADAM17 | P78536 | 1/20 | 0.43 |
| ▸ | MMP12 | P39900 | 1/20 | 0.43 |
| ▸ | MMP13 | P45452 | 1/20 | 0.43 |
| ▸ | MMP14 | P50281 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7427886 | 0.94 | MMP1 (0.47) | MMP1REN | |
| SCHEMBL8764718 | 0.85 | MMP1 (0.50) | MMP1MMP3MMP8MMP2MMP9 | |
| SCHEMBL8764285 | 0.84 | MMP1 (0.53) | MMP1RENMMP2MMP9MMP7 | |
| SCHEMBL7488102 | 0.83 | MMP1 (0.47) | MMP1RENMMP3MMP8MMP2 | |
| SCHEMBL7383157 | 0.81 | MMP1 (0.62) | MMP1RENMMP3MMP8MMP2 | |
| SCHEMBL7424246 | 0.81 | MMP1 (0.62) | MMP1RENMMP3MMP8MMP2 | |
| SCHEMBL7426252 | 0.81 | MMP1 (0.62) | MMP1RENMMP3MMP8MMP2 | |
| SCHEMBL6413299 | 0.81 | MMP1 (0.62) | MMP1RENMMP3MMP8MMP2 | |
| SCHEMBL7480288 | 0.79 | MMP1 (0.53) | MMP1REN | |
| SCHEMBL7428922 | 0.78 | MMP1 (0.63) | MMP1RENMMP3MMP8MMP2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1047450-A1 | ACE INHIBITOR-MMP INHIBITOR COMBINATIONS | WARNER-LAMBERT COMPANY (US) | 2000-11-02 | — | — | EP | disclosed |
| WO-1999032150-A1 | ACE INHIBITOR-MMP INHIBITOR COMBINATIONS | WARNER-LAMBERT COMPANY (US) | 1999-07-01 | — | — | WO | disclosed |