Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP1 | P03956 | 5/20 | 0.53 |
| ▸ | ACE | P12821 | 3/20 | 0.50 |
| ▸ | MME | P08473 | 3/20 | 0.49 |
| ▸ | CPA1 | P15085 | 1/20 | 0.49 |
| ▸ | ACE2 | Q9BYF1 | 1/20 | 0.49 |
| ▸ | REN | P00797 | 1/20 | 0.47 |
| ▸ | CAPN1 | P07384 | 2/20 | 0.47 |
| ▸ | MMP2 | P08253 | 1/20 | 0.46 |
| ▸ | MMP7 | P09237 | 1/20 | 0.46 |
| ▸ | MMP9 | P14780 | 1/20 | 0.46 |
| ▸ | MMP12 | P39900 | 1/20 | 0.46 |
| ▸ | MMP13 | P45452 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7427886 | 0.91 | MMP1 (0.47) | MMP1ACEMMECPA1ACE2 | |
| SCHEMBL7426256 | 0.84 | MMP1 (0.54) | MMP1RENMMP2MMP7MMP9 | |
| SCHEMBL7480288 | 0.82 | MMP1 (0.53) | MMP1MMERENCAPN1 | |
| SCHEMBL998948 | 0.80 | MME (0.54) | MMECAPN1 | |
| SCHEMBL31512922 | 0.80 | CTSK (0.56) | ACEMMECPA1ACE2CAPN1 | |
| SCHEMBL8390276 | 0.79 | MME (0.68) | MMP1ACEMMECPA1ACE2 | |
| SCHEMBL8764718 | 0.77 | MMP1 (0.50) | MMP1MMP2MMP7MMP9 | |
| SCHEMBL7488102 | 0.75 | MMP1 (0.47) | MMP1RENCAPN1MMP2MMP7 | |
| SCHEMBL7424750 | 0.73 | MMP1 (0.46) | MMP1RENCAPN1MMP2 | |
| SCHEMBL5934705 | 0.72 | CTSK (0.58) | CAPN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0784629-A1 | PEPTIDYL COMPOUNDS AND THEIR THERAPEUTIC USE AS INHIBITORS OF METALLOPROTEASES | Chiroscience Limited (GB) | 1997-07-23 | — | — | EP | claimed |
| WO-1996011209-A1 | PEPTIDYL COMPOUNDS AND THEIR THERAPEUTIC USE AS INHIBITORS OF METALLOPROTEASES | CHIROSCIENCE LIMITED (GB) | 1996-04-18 | — | — | WO | claimed |