SCHEMBL7426505

SCHEMBL7426505

COc1ccccc1-n1ccnc1SC

nearest known ligand 0.59

Predicted protein targets (top 16)

geneUniProtsupporting neighboursconfidence
CYP1A2 P05177 1/20 0.59
CYP3A4 P08684 1/20 0.59
CYP2C9 P11712 1/20 0.59
CYP2C19 P33261 1/20 0.59
SMN1; SMN2 Q16637 3/20 0.56
GAA P10253 1/20 0.48
ALDH1A1 P00352 1/20 0.47
TSHR P16473 2/20 0.46
KMT2A Q03164 2/20 0.46
MEN1 O00255 1/20 0.43
NR4A1 P22736 1/20 0.42
NR4A2 P43354 1/20 0.42
L3MBTL1 Q9Y468 2/20 0.42
HCAR1 Q9BXC0 1/20 0.42
LMNA P02545 2/20 0.40
TP53 P04637 1/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL10904420 0.79 GAA (0.47) CYP3A4SMN1; SMN2GAAALDH1A1TSHR
SCHEMBL9731132 0.75 KCNN4 (0.47) CYP1A2CYP3A4CYP2C19SMN1; SMN2GAA
SCHEMBL15921015 0.72 SMN1; SMN2 (0.42) SMN1; SMN2GAAALDH1A1TSHRKMT2A
SCHEMBL15921161 0.72 SMN1; SMN2 (0.42) CYP2C19SMN1; SMN2GAAALDH1A1TSHR
Hydrochloric Acid SCHEMBL11387397 0.70 NR4A1 (0.57) CYP1A2CYP3A4CYP2C9CYP2C19SMN1; SMN2
SCHEMBL15933329 0.70 SMN1; SMN2 (0.43) SMN1; SMN2GAAALDH1A1KMT2AMEN1
SCHEMBL15921413 0.67 SMN1; SMN2 (0.48) SMN1; SMN2GAAALDH1A1TSHRKMT2A
SCHEMBL22471127 0.67 NR4A1 (0.62) CYP1A2CYP3A4CYP2C9CYP2C19SMN1; SMN2
SCHEMBL27949777 0.67 ATP4A (0.48) CYP1A2CYP3A4CYP2C19KMT2ALMNA
SCHEMBL3433008 0.66 GAA (0.60) CYP2C19GAAALDH1A1KMT2AMEN1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6200991-B1 M3-MUSCARINIC OR 5-HT SEROTONINERGIC RECEPTOR ANTAGONISTS; IRRITABLE BOWEL SYNDROME, INCONTINENCE, COGNITION ACTIVATORS; RESPIRATORY SYSTEM DISORDERS SANOFI-SYNTHELABO (FR) 2001-03-13 US disclosed
EP-1032569-A1 IMIDAZOLE DERIVATIVES, PREPARATION AND THERAPEUTIC APPLICATION THEREOF SANOFI-SYNTHELABO (FR) 2000-09-06 EP disclosed
WO-1999025710-A1 IMIDAZOLE DERIVATIVES, PREPARATION AND THERAPEUTIC APPLICATION THEREOF SANOFI-SYNTHELABO (FR) 1999-05-27 WO disclosed
WO-1996003387-A1 4,5-SUBSTITUTED IMIDAZOLYL COMPOUNDS FOR THE TREATMENT OF INFLAMMATION G.D. SEARLE & CO. (US) 1996-02-08 WO disclosed