Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR132 | Q9UNW8 | 9/20 | 0.50 |
| ▸ | CYP27B1 | O15528 | 1/20 | 0.47 |
| ▸ | CYP24A1 | Q07973 | 1/20 | 0.47 |
| ▸ | CTSK | P43235 | 3/20 | 0.43 |
| ▸ | CTSL | P07711 | 2/20 | 0.43 |
| ▸ | CTSS | P25774 | 2/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | CTSB | P07858 | 1/20 | 0.42 |
| ▸ | ITGB3 | P05106 | 1/20 | 0.41 |
| ▸ | ITGA2B | P08514 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.41 |
| ▸ | MME | P08473 | 1/20 | 0.41 |
| ▸ | ACE | P12821 | 1/20 | 0.41 |
| ▸ | CPA1 | P15085 | 1/20 | 0.41 |
| ▸ | ACE2 | Q9BYF1 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7424457 | 0.88 | NR4A2 (0.48) | GPR132CTSKKMT2AMEN1 | |
| SCHEMBL7421871 | 0.88 | CTSK (0.48) | GPR132CYP27B1CYP24A1CTSKCTSL | |
| SCHEMBL7425598 | 0.87 | KMT2A (0.41) | GPR132CTSKKMT2AMEN1SMN1; SMN2 | |
| SCHEMBL7424536 | 0.86 | MAPK1 (0.42) | CTSKKMT2AMEN1SMN1; SMN2ALOX5 | |
| SCHEMBL7427134 | 0.86 | MEN1 (0.41) | CTSKKMT2AMEN1ALOX5 | |
| SCHEMBL7421897 | 0.85 | NR4A2 (0.49) | — | |
| SCHEMBL7420340 | 0.84 | MAPT (0.44) | CTSKCTSLCTSSMME | |
| SCHEMBL7424286 | 0.81 | NR4A2 (0.49) | GPR132KMT2AMEN1 | |
| SCHEMBL5869757 | 0.78 | GPR132 (0.60) | GPR132CTSKCTSLCTSSMME | |
| SCHEMBL5869635 | 0.78 | GPR132 (0.60) | GPR132CTSKCTSLCTSSMME |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2002039997-A2 | ACE-2 MODULATING COMPOUNDS AND USE THEREOF | MILLENNIUM PHARMACEUTICALS, INC. (US) | 2002-05-23 | — | — | WO | claimed |
| WO-2002039997-A2 | ACE-2 MODULATING COMPOUNDS AND USE THEREOF | MILLENNIUM PHARMACEUTICALS, INC. (US) | 2002-05-23 | — | — | WO | disclosed |